KAT2B - lysine acetyltransferase 2B Gene

Rattus norvegicus

Also known as Pcaf; AABR07066180.1

Gene ID: 301164 | Gene type: protein coding

About KAT2B

Primary_assembly 9: 6,562,288-6,667,064 forward strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 226 orthologues, 11 paralogues and is associated with 4 phenotypes. Biased expression in Muscle (RPKM 351.2), Heart (RPKM 315.7) and 9 other tissues.

Summary

Enables chromatin binding activity; Histone Acetyltransferase binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; positive regulation of chromatin binding activity; and positive regulation of histone acetylation. Located in chromatin; cytosol; and nucleus. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]

KAT2B Products(5)

mRNA	Protein	Name
XM_039084397.1	XP_038940325.1	histone acetyltransferase KAT2B isoform X2
XM_039084398.1	XP_038940326.1	histone acetyltransferase KAT2B isoform X3
XM_039084400.1	XP_038940328.1	histone acetyltransferase KAT2B isoform X5
XM_039084399.1	XP_038940327.1	histone acetyltransferase KAT2B isoform X4
XM_039084396.1	XP_038940324.1	histone acetyltransferase KAT2B isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	20870727	RGD
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	20870727	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	24526703	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18042454	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	18945670	RGD
involved in cellular response to parathyroid hormone stimulus	IEP IEP: Inferred from expression pattern	20870727	RGD
involved in memory	IEP IEP: Inferred from expression pattern	20811339	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	20094059	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20870727	RGD
involved in protein acetylation	IMP IMP: Inferred from mutant phenotype	22859492	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	22859492	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20870727	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KAT2B Protein Structure

PCAF_N

COG5076

Bromo_gcn5_like

0
200
400
600
813 a.a.

Protein Preferred Names

Protein Names

histone acetyltransferase KAT2B

K(lysine) acetyltransferase 2B

p300/CBP-associated factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W015239	KAT8-IN-1		99.40%	Unkown
HY-RS07077	KAT2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07078	Kat2b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07079	KAT2B Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	KAT2B	NCBI	NCBI:8850

Name
Email *

	Sorry, but the email address you supplied was invalid.