Arpc2 - actin related protein 2/3 complex, subunit 2 Gene

Rattus norvegicus

Also known as p34Arc

Gene ID: 301511 | Gene type: protein coding

About Arpc2

Primary_assembly 9: 75,820,770-75,851,471 forward strand.mRatBN7.2:CM026982.1

This gene has 5 transcripts (splice variants), 241 orthologues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 125.8), Thymus (RPKM 929.) and 9 other tissues.

Summary

Enables several functions, including AP-1 adaptor complex binding activity; ATPase binding activity; and Arp2/3 complex binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to rapamycin; and positive regulation of cellular component organization. Located in several cellular components, including actin cytoskeleton; dendrite; and distal axon. Part of filamentous actin. Biomarker of silicosis. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Arpc2 Products(1)

mRNA	Protein	Name
NM_001106919.1	NP_001100389.1	actin-related protein 2月3日 complex subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AP-1 adaptor complex binding	IDA IDA: Inferred from direct assay	22689987	RGD
enables ATPase binding	IPI IPI: Inferred from physical interaction	18297063	RGD
enables Arp2/3 complex binding	IDA IDA: Inferred from direct assay	22689987	RGD
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	18297063	RGD
enables kinesin binding	IDA IDA: Inferred from direct assay	22689987	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17456547	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17350576	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to epidermal growth factor stimulus	IMP IMP: Inferred from mutant phenotype	15252126	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	24152438	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	10797548	RGD
involved in cellular response to platelet-derived growth factor stimulus	IDA IDA: Inferred from direct assay	22619279	RGD
involved in cellular response to rapamycin	IDA IDA: Inferred from direct assay	11598004	RGD
involved in positive regulation of barbed-end actin filament capping	IMP IMP: Inferred from mutant phenotype	15252126	RGD
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	18256280	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	15252126	RGD
involved in positive regulation of podosome assembly	IMP IMP: Inferred from mutant phenotype	17224451	RGD
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	20739464	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	24152438	RGD
involved in protein kinase C signaling	IDA IDA: Inferred from direct assay	16027158	RGD
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20739464	RGD
involved in response to silicon dioxide	IEP IEP: Inferred from expression pattern	18685790	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18509026	RGD
located in actin filament branch point	IDA IDA: Inferred from direct assay	18256280	RGD
located in apical dendrite	IDA IDA: Inferred from direct assay	18509026	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	18509026	RGD
located in cell leading edge	IDA IDA: Inferred from direct assay	16027158	RGD
located in cell surface	IDA IDA: Inferred from direct assay	11598004	RGD
located in concave side of sperm head	IDA IDA: Inferred from direct assay	23403943	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	18509026	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	18509026	RGD
part of filamentous actin	IDA IDA: Inferred from direct assay	10797548	RGD
located in growth cone	IDA IDA: Inferred from direct assay	10797548	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	15684033	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	18509026	RGD
located in peripheral region of growth cone	IDA IDA: Inferred from direct assay	18256280	RGD
located in podosome core	IDA IDA: Inferred from direct assay	17224451	RGD
located in podosome ring	IDA IDA: Inferred from direct assay	17224451	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	18509026	RGD
located in ruffle membrane	IDA IDA: Inferred from direct assay	17224451	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	14617808	RGD
located in ventral surface of cell	IDA IDA: Inferred from direct assay	11598004	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Arpc2 Protein Structure

P34-Arc

0
100
200
300 a.a.

Protein Preferred Names

Protein Names

actin-related protein 2/3 complex subunit 2

arp2/3 complex 34 kDa subunit

p34-ARC

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114657A	Benproperine phosphate	Inhibitor	99.93%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01015	ARPC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01016	Arpc2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01017	Arpc2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arpc2	NCBI	NCBI:10109

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