Ccr6 - C-C motif chemokine receptor 6 Gene

Rattus norvegicus

Gene ID: 308163 | Gene type: protein coding

About Ccr6

Primary_assembly 1: 52,474,168-52,498,603 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 299 orthologues, 24 paralogues and is associated with 20 phenotypes. Biased expression in Spleen (RPKM 8.7), Thymus (RPKM 21.) and 1 other tissue.

Summary

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in positive regulation of cytosolic calcium ion concentration; positive regulation of dendritic cell chemotaxis; and positive regulation of epithelial cell migration. Predicted to be located in cell surface; sperm flagellum; and sperm plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of membranoproliferative glomerulonephritis and transient cerebral ischemia. Orthologous to human CCR6 (C-C motif Chemokine Receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Ccr6 Products(1)

mRNA	Protein	Name
NM_001013145.1	NP_001013163.1	C-C chemokine receptor type 6

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	19233848	RGD
involved in positive regulation of dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	14673014	RGD
involved in positive regulation of epithelial cell migration	IDA IDA: Inferred from direct assay	19233848	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr6 Protein Structure

7tmA_CCR6

0
100
200
300
366 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 6

CC chemokine receptor 6

chemokine (C-C motif) receptor 6

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148531	PF-07054894	Inhibitor	99.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151435	CCR6 antagonist 1	Antagonist	99.55%	Unkown
HY-112701	CCR6 inhibitor 1	Inhibitor	99.60%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr6	NCBI	NCBI:1235

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