CD209 - CD209 molecule Gene

Homo sapiens

Also known as CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN

Gene ID: 30835 | Gene type: protein coding

About CD209

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,739,993-7,747,534 (from NCBI)

This gene has 11 transcripts (splice variants), 891 orthologues, 14 paralogues and is associated with 68 phenotypes. Broad expression in placenta (RPKM 11.4), lymph node (RPKM 9.5) and 17 other tissues.

Summary

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 Infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]

CD209 Products(7)

mRNA	Protein	Name
NM_001144893.2	NP_001138365.1	CD209 antigen isoform 5
NM_001144894.2	NP_001138366.1	CD209 antigen isoform 6
NM_001144895.2	NP_001138367.1	CD209 antigen isoform 7
NM_001144896.2	NP_001138368.1	CD209 antigen isoform 3
NM_001144897.2	NP_001138369.1	CD209 antigen isoform 4
NM_001144899.2	NP_001138371.1	CD209 antigen isoform 8
NM_021155.4	NP_066978.1	CD209 antigen isoform 1

CD209 Protein Structure

Lectin_C

0
100
200
300
404 a.a.

Protein Preferred Names

Protein Names

CD209 antigen

C-type lectin domain family 4 member L

Recombinant CD209 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70110	DC-SIGN/CD209 Protein, Human (HEK293, Fc)	Q9NNX6-1 (Q59-A404)	≥95%

Related Diseases

Diseases

Alias

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Rift Valley Fever

Rfv - [Rift Valley Fever]

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

West Nile Virus

West Nile Virus, Susceptibility To	Wnv
Wnv, Susceptibility To	West Nile Viral Infection
Encephalitis, West Nile Fever	West Nile Fever

Dengue Disease

Dengue Fever	Dengue
Df	Dengue Shock Syndrome
Dengue Virus Infection	Breakbone Fever
Classic Dengue	Classical Dengue
Dengue Hemorrhagic Fever	Hemorrhagic Dengue
Philippine Hemorrhagic Fever	Singapore Hemorrhagic Fever
Thai Hemorrhagic Fever	Severe Dengue
Dengue Fever Without Warning Signs	Dengue Haemorrhagic Fever Grade 1
Dengue Haemorrhagic Fever Without Warning Signs	Bangkok Haemorrhagic Fever
Singapore Haemorrhagic Fever	Thailand Haemorrhagic Fever
Southeast Asia Haemorrhagic Fever	Dhf -[Dengue Haemorrhagic Fever]
Dengue Fever With Warning Signs	Dengue Haemorrhagic Fever With Warning Signs
Dengue Haemorrhagic Fever Grade 2	Philippine Haemorrhagic Fever

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Syphilis

Chancre

Syphilitic Chancre

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Zika Fever

Zika Virus Infection	Zika Virus Disease
Zika Virus	Zika Virus Fever
Mosquito-Borne Viral Fever, Zika

Papilloma

Papillomatosis

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Adenitis	Chronic Adenitis
Acute Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Paracoccidioidomycosis

Mucocutaneous-Lymphangitic Paracoccidioidomycosis	Paracoccidioidal Mycosis
Lobo Disease	Lutz-Splendore-Almeida Disease
Pcm	Paracoccidioidal Granuloma
South American Blastomycosis	Lobomycosis
Brazilian Blastomycosis	Lutz Disease
Brazilian Blastomycotic	South American Blastomyces Infection
Paracoccidioides Brasiliensis Infection	Paracoccidioidomycosis Unspecified

Lymphocytic Choriomeningitis

Lcm	Lymphocytic Meningitis
Lymphocytic Choriomeningitis Virus Encephalomyelitis	Lymphocytic Meningoencephalitis
Non-Arthropod Borne Lymphocytic Choriomeningitis	Lcm - [Lymphocytic Choriomeningitis]
Benign Lymphocytic Meningitis	Meningitis Due To Lymphocytic Choriomeningitis Virus

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Severe Acute Respiratory Syndrome

Sars	Sars-Cov Infection
Sars-1	Sar Deficiency
Sars - [Severe Acute Respiratory Syndrome]

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Dengue Hemorrhagic Fever

Severe Dengue	Dengue Haemorrhagic Fever
Dhf	Severe Dengue Haemorrhagic Fever
Severe Dengue Fever	Dengue Shock Syndrome

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis	Encephalitis, Tick-Borne
Central European Encephalitis	Far Eastern Tbe
Russian Spring-Summer Encephalitis	Taiga Encephalitis
West-Siberian Encephalitis	Western European Tick-Borne Encephalitis
Tbe	Encephalitis Tick-Borne
Encephalitis, Central European	Encephalitis, Far Eastern Russian

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Mouth Disease

Mouth Diseases

Mouth Disorders

Dengue Shock Syndrome

Dss

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Invasive Aspergillosis

Aspergillosis Invasive

Miyoshi Muscular Dystrophy 3

MMD3	Miyoshi Myopathy 3
Distal Anoctaminopathy	Miyoshi Muscular Dystrophy Type 3
Dystrophy, Muscular, Miyoshi, Type 3

Cutaneous Leishmaniasis

Diffuse Cutaneous Leishmaniasis	Asian Desert Cutaneous Leishmaniasis
Leishmaniasis, Cutaneous	Leproid Leishmaniasis
Leishmaniasis Diffuse Cutaneous	Leishmaniasis Cutaneous
Ethiopian Cutaneous Leishmaniasis	Old World Cutaneous Leishmaniasis

Tuberculoid Leprosy

Smooth Leprosy	Type T Leprosy
Leprosy Tuberculoid	Leprosy, Tuberculoid

West Nile Fever

Murray Valley Encephalitis

Australian Encephalitis	Australian X Disease
Encephalitis Australia	Murray River Encephalitis
Australian Arboencephalitis	Australian X Disorder
Mve - [Murray Valley Encephalitis]

Lassa Fever

Lf	Lassa Hemorrhagic Fever
Lf - [Lassa Fever]

Lepromatous Leprosy

Leprosy, Lepromatous	Type L Leprosy
Leprosy Lepromatous

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Fungal Infectious Disease

Mycoses

Mycosis

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Primary Bacterial Infectious Disease

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02209	CD209 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CD209	RGD	RGD:1561104
Mus musculus	CD209	NCBI
Macaca mulatta	CD209	NCBI	NCBI:574211
Others	CD209	NCBI