Mttp - microsomal triglyceride transfer protein Gene

Rattus norvegicus

Also known as MTP

Gene ID: 310900 | Gene type: protein coding

About Mttp

Primary_assembly 2: 226,613,090-226,654,239 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 210 orthologues and is associated with 11 phenotypes.

Summary

Enables Apolipoprotein binding activity and lipid transfer activity. Involved in several processes, including Cholesterol homeostasis; lipoprotein metabolic process; and response to calcium ion. Located in several cellular components, including basolateral plasma membrane; cell projection membrane; and rough endoplasmic reticulum. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2022]

Mttp Products(1)

mRNA	Protein	Name
NM_001107727.1	NP_001101197.1	microsomal triglyceride transfer protein large subunit precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables apolipoprotein binding	IPI IPI: Inferred from physical interaction	11830580	RGD
enables cholesterol transfer activity	IDA IDA: Inferred from direct assay	15897609	RGD
enables lipid transporter activity	IDA IDA: Inferred from direct assay	15383310	RGD
enables phosphatidylcholine transfer activity	IMP IMP: Inferred from mutant phenotype	16478722	RGD
enables phosphatidylethanolamine transfer activity	IDA IDA: Inferred from direct assay	15897609	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	11830580	RGD
enables triglyceride transfer activity	IDA IDA: Inferred from direct assay	15897609	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholesterol homeostasis	IEP IEP: Inferred from expression pattern	14972350	RGD
involved in lipid transport	IDA IDA: Inferred from direct assay	15383310	RGD
involved in lipoprotein metabolic process	IDA IDA: Inferred from direct assay	11830580	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	16651714	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11830580	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	15383310	RGD
located in microvillus membrane	IDA IDA: Inferred from direct assay	15383310	RGD
located in vesicle	IDA IDA: Inferred from direct assay	15383310	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microsomal triglyceride transfer protein large subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08822	MTTP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08823	Mttp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08824	Mttp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mttp	NCBI	NCBI:4547

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