HLA-DQA2 - major histocompatibility complex, class II, DQ alpha 2 Gene

Homo sapiens

Also known as DQA1; HLA-DCA; HLA-DXA; HLADQA2; DC-alpha; DX-ALPHA

Gene ID: 3118 | Gene type: protein coding

About HLA-DQA2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,741,391-32,747,198 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 542 orthologues, 13 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 32.9), spleen (RPKM 26.8) and 20 other tissues.

Summary

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic Peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]

HLA-DQA2 Products(1)

mRNA	Protein	Name
NM_020056.5	NP_064440.1	HLA class II histocompatibility antigen, DQ alpha 2 chain precursor

HLA-DQA2 Protein Structure

MHC_II_alpha

C1-set

0
100
200
255 a.a.

Protein Preferred Names

Protein Names

HLA class II histocompatibility antigen, DQ alpha 2 chain

DC-1 alpha chain

Related Diseases

Diseases

Alias

Penis Carcinoma In Situ

Carcinoma In Situ Of Penis	Bowen'S Disease Of Penis
Grade Iii Squamous Intraepithelial Lesion Of Penis	Penile Intraepithelial Neoplasia Grade Iii
Queyrat'S Erythroplasia	Erythroplasia Of Queyrat
Pin - [Penile Intraepithelial Neoplasia]

Podoconiosis

PDCOS	Podoconiosis, Susceptibility To
Nonfilarial Elephantiasis Of Lower Legs	Nonfilarial Elephantiasis Of Lower Legs, Susceptibility To
Endemic Nonfilarial Elephantiasis	Endemic Nonfilarial Elephantiasis, Susceptibility To
Lymphostatic Verrucosis	Lymphostatic Verrucosis, Susceptibility To
Elephantiasis	Endemic Non-Filarial Elephantiasis

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Type 1 Diabetes Mellitus 12

Diabetes Mellitus, Insulin-Dependent, 12	IDDM12
Insulin-Dependent Diabetes Mellitus 12	T1D12
Type 1 Diabetes Mellitus 12, Susceptibility To	Diabetes Mellitus, Insulin-Dependent, Type 12

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Gastroduodenal Crohn'S Disease

Upper Gi Crohn'S Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06206	HLA-DQA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HLA-DQA2	MGD	MGI:95895

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