ABL1 - ABL proto-oncogene 1, non-receptor tyrosine kinase Gene

Rattus norvegicus

Also known as Abl

Gene ID: 311860 | Gene type: protein coding

About ABL1

Primary_assembly 3: 14,979,853-15,083,065 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 204 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in Kidney (RPKM 15.7), Lung (RPKM 94.8) and 9 other tissues.

Summary

Enables delta-catenin binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including glomerular visceral epithelial cell apoptotic process; positive regulation of cellular component organization; and positive regulation of programmed cell death. Located in several cellular components, including growth cone; neuronal cell body; and ruffle. Biomarker of Parkinson's disease and ureteral obstruction. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

ABL1 Products(1)

mRNA	Protein	Name
NM_001100850.1	NP_001094320.1	tyrosine-protein kinase ABL1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables delta-catenin binding	IDA IDA: Inferred from direct assay	11891774	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10679771	RGD
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	15629889	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19700222	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament polymerization	IMP IMP: Inferred from mutant phenotype	17615370	RGD
involved in associative learning	IEP IEP: Inferred from expression pattern	23532861	RGD
involved in cardiac muscle cell proliferation	IEP IEP: Inferred from expression pattern	2447874	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	20883783	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	15629889	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	18559370	RGD
involved in myoblast proliferation	IEP IEP: Inferred from expression pattern	2425941	RGD
involved in podocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	23515840	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15474370	RGD
involved in positive regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	15456825	RGD
involved in positive regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	19846571	RGD
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	19846571	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18559370	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	17615370	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	9583675	RGD
involved in regulation of modification of synaptic structure	IGI IGI: Inferred from genetic interaction	24658113	RGD
involved in regulation of postsynaptic specialization assembly	EXP EXP: Inferred from Experiment	20220006	RGD
involved in regulation of postsynaptic specialization assembly	IDA IDA: Inferred from direct assay	20220006	RGD
involved in regulation of postsynaptic specialization assembly	IMP IMP: Inferred from mutant phenotype	20220006	RGD
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11509666	RGD
involved in response to epinephrine	IEP IEP: Inferred from expression pattern	2166578	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20519366	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	24658113	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	20220006	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20220006	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20220006	RGD
located in growth cone	IDA IDA: Inferred from direct assay	11891774	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	24412932	RGD
located in nucleus	IDA IDA: Inferred from direct assay	24658113	RGD
is active in postsynaptic density	EXP EXP: Inferred from Experiment	20220006	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	20220006	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	20220006	RGD
located in ruffle	IDA IDA: Inferred from direct assay	16831423	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABL1 Protein Structure

SH3_Abl

SH2_ABL

PTKc_Abl

FABD

0
200
400
600
800
1000
1143 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase ABL1

Abelson murine leukemia viral (v-abl) oncogene homolog 1	c-abl oncogene 1, non-receptor tyrosine kinase
c-abl oncogene 1, receptor tyrosine kinase	tyrosine-protein kinase ABL1-like
v-abl Abelson murine leukemia viral oncogene 1

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104010	Asciminib	Inhibitor	99.88%	Yes
HY-15728	Radotinib		98.92%	Yes
HY-104010A	Asciminib hydrochloride	Inhibitor	99.84%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13024	Rebastinib		99.91%	Phase 2
HY-137460	Vodobatinib	Inhibitor	99.85%	Phase 2
HY-148794	Risvodetinib	Inhibitor	99.21%	Phase 2
HY-13072	Cenisertib	Inhibitor	99.86%	Phase 1

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-125834	GMB-475		98.98%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.34%	Unkown
HY-W143698	PDGFRα kinase inhibitor 2	Inhibitor	98.95%	Unkown
HY-145887	BCR-ABL1-IN-1		99.82%	Unkown
HY-12338	ON 146040	Inhibitor	95.05%	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-107447S	N-Deshydroxyethyl Dasatinib-d8		/	Unkown
HY-101268	CHMFL-ABL-053	Inhibitor	/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-119177	PD173956	Inhibitor	/	Unkown
HY-130297	PROTAC BCR-ABL1 ligand 1	Inhibitor	/	Unkown
HY-14979	ML786	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-155112	Antiproliferative agent-30	Inhibitor	/	Unkown
HY-161445	(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH		/	Unkown
HY-162489	Tyrosine kinase-IN-8	Inhibitor	/	Unkown
HY-162952	cSRC/BCR-ABL1-IN-1	Inhibitor	/	Unkown
HY-171146	HSN748	Inhibitor	/	Unkown
HY-18819	BCR-ABL-IN-2	Inhibitor	/	Unkown
HY-RS00102	ABL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00103	Abl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00104	ABL1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-13072B	Cenisertib benzoate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ABL1	NCBI	NCBI:25

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