2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. FLT3 Bcr-Abl RET PDGFR MNK
  4. HSN748

HSN748 is a Ponatinib (HY-12047) analogue and a multikinase inhibitor. HSN748 has inhibitory activity on FLT3, ABL1, RET, PDGFRα/β, MNK1, MNK2 and other kinases. HSN748 can inhibit the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines and can be used in the study of leukemia.

For research use only. We do not sell to patients.

HSN748 Chemical Structure

HSN748 Chemical Structure

CAS No. : 2409925-53-5

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HSN748 Related Antibodies

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MNK1 MNK2 MNK

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Description

HSN748 is a Ponatinib (HY-12047) analogue and a multikinase inhibitor. HSN748 has inhibitory activity on FLT3, ABL1, RET, PDGFRα/β, MNK1, MNK2 and other kinases. HSN748 can inhibit the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines and can be used in the study of leukemia[1].

IC50 & Target[1]

PDGFRα

 

PDGFRβ

 

MNK1

 

MNK2

 

Molecular Weight

519.52

Formula

C27H24F3N7O
CAS No.
SMILES

O=C(C1=CC(C#CC2=CN=C3C=CC=NN23)=CN=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSN748 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSN7482409925-53-5HSN 748HSN-748FLT3Bcr-AblRETPDGFRMNKCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Platelet-derived growth factor receptorMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseCMLAMLInhibitorinhibitorinhibit

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