ABL1 - ABL proto-oncogene 1, non-receptor tyrosine kinase Gene

Homo sapiens

Also known as ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl

Gene ID: 25 | Gene type: protein coding

About ABL1

Cytogenetic location: 9q34.12 Genomic coordinates (GRCh38): 9:130,713,043-130,887,675 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues, 32 paralogues and is associated with 141 phenotypes. Ubiquitous expression in endometrium (RPKM 24.7), gall bladder (RPKM 20.6) and 25 other tissues.

Summary

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

ABL1 Products(2)

mRNA	Protein	Name
NM_007313.3	NP_009297.2	tyrosine-protein kinase ABL1 isoform b
NM_005157.6	NP_005148.2	tyrosine-protein kinase ABL1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9144171	GOA
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	12384576	GOA
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	7590236	GOA
enables bubble DNA binding	IDA IDA: Inferred from direct assay	9558345	GOA
enables four-way junction DNA binding	IDA IDA: Inferred from direct assay	9558345	GOA
enables kinase activity	IMP IMP: Inferred from mutant phenotype	28288113	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9144171	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	9144171	GOA
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	11121037	GOA
enables neuropilin binding	IPI IPI: Inferred from physical interaction	24863063	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9461559	GOA
enables non-membrane spanning protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	28428613	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables proline-rich region binding	IDA IDA: Inferred from direct assay	15657060	GOA
enables proline-rich region binding	IPI IPI: Inferred from physical interaction	7590236	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7590236	GOA
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	10713049	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	11120811	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	24863063	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	15657136	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7590236	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	22810897	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	9558345	GOA
NOT enables supercoiled DNA binding	IDA IDA: Inferred from direct assay	9558345	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	23006999	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA conformation change	IDA IDA: Inferred from direct assay	9558345	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	15657060	GOA
involved in activation of protein kinase C activity	IDA IDA: Inferred from direct assay	10713049	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	10713049	GOA
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	9461559	GOA
involved in negative regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11121037	GOA
acts upstream of or within negative regulation of ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20823226	GOA
involved in neuropilin signaling pathway	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in peptidyl-tyrosine autophosphorylation	IMP IMP: Inferred from mutant phenotype	24520051	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7590236	GOA
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	24520051	GOA
acts upstream of or within phospholipase C-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24367707	GOA
involved in platelet-derived growth factor receptor-beta signaling pathway	IMP IMP: Inferred from mutant phenotype	24520051	GOA
involved in positive regulation of actin filament binding	IMP IMP: Inferred from mutant phenotype	24520051	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9037071	GOA
acts upstream of or within positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	24367707	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in positive regulation of microtubule binding	IMP IMP: Inferred from mutant phenotype	24520051	GOA
involved in positive regulation of oxidoreductase activity	IDA IDA: Inferred from direct assay	12893824	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	15657060	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24700464	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10713049	GOA
involved in protein localization to cytoplasmic microtubule plus-end	IMP IMP: Inferred from mutant phenotype	24520051	GOA
involved in regulation of Cdc42 protein signal transduction	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24520051	GOA
involved in regulation of axon extension	IMP IMP: Inferred from mutant phenotype	24520051	GOA
involved in regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	24520051	GOA
acts upstream of or within response to oxidative stress	IGI IGI: Inferred from genetic interaction	17626041	GOA
involved in signal transduction in response to DNA damage	IDA IDA: Inferred from direct assay	9037071	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17515907	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11120811	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12944467	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9168116	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17888034	GOA
part of protein-containing complex	IPI IPI: Inferred from physical interaction	12384576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABL1 Protein Structure

SH3_1

SH2

Pkinase_Tyr

F_actin_bind

0
200
400
600
800
1000
1130 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase ABL1

ABL protooncogene 1 nonreceptor tyrosine kinase	Abelson tyrosine-protein kinase 1
BCR-ABL1 p190	BCR/ABL e8a2 fusion
BCR/ABL1 e1a2 fusion protein	bcr/c-abl oncogene protein
c-abl oncogene 1, receptor tyrosine kinase	proto-oncogene c-Abl
proto-oncogene tyrosine-protein kinase ABL1	v-abl Abelson murine leukemia viral oncogene homolog 1

Recombinant ABL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71685	ABL1 Protein, Human (GST)	P00519 (I4-T194)	≥95%
HY-P77308	ABL1 Protein, Human (sf9, GST)	P00519-2 (P137-S554)	≥95%

Related Diseases

Diseases

Alias

Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement

Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement

Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement

Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukaemia	Atypical Chronic Myeloid Leukemia
Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative	Acml
Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative
Atypical Cml	Subacute Myeloid Leukemia
Subacute Myelogenous Leukaemia	Subacute Myeloid Leukaemia
Subacute Myelosis	Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission
Subacute Monocytic Leukaemia Without Mention Of Remission	Subacute Monocytic Leukaemia

Moyamoya Angiopathy

Bone Marrow Cancer

Malignant Neoplasm Of Bone Marrow	Bone Marrow Neoplasm
Bone Marrow Tumor	Malignant Bone Marrow Tumor
Myeloproliferative Disorders	Bone Marrow Neoplasms
Myeloproliferative Disease	Chronic Myeloproliferative Disorder

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Acute Basophilic Leukemia

Hematologic Cancer

Hematologic Neoplasm	Hematologic Malignancies
Hematologic Neoplasms	Blood Cancer
Hematologic Malignancy	Hematological Tumors
Hematopoietic And Lymphoid System Tumor	Hematopoietic Cancer
Hematopoietic Neoplasm	Hematopoietic Tumors
Malignant Hematopoietic Neoplasm	Liquid Tumor
Hematopoietic Neoplasms

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Chronic Myelogenous Leukemia, Bcr-Abl1 Positive

Chronic Myelogenous Leukemia, Bcr/Abl Positive	Chronic Myelosis
Chronic Myeloid Leukaemia, Bcr-Abl-Positive Without Mention Of Remission

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

B-Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like

B Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like

B-All Bcr-Abl1-Like

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Acute Leukemia

Stem Cell Leukaemia	Stem Cell Leukemia
Acute Leukemias	Acute Undifferentiated Leukemia
Undifferentiated Leukemia	Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission
Blast Cell Leukaemia	Blast Leukaemia
Blastic Leukaemia	Undifferentiated Leukaemia

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Megabladder, Congenital

MGBL	Congenital Megabladder

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Myelodysplastic/Myeloproliferative Neoplasm

Myelodysplastic/Myeloproliferative Disease	Myelodysplastic-Myeloproliferative Diseases
Myelodysplastic Myeloproliferative Cancer	Myelodysplastic Myeloproliferative Disease
Myeloproliferative/Myelodysplastic Syndromes

Lip And Oral Cavity Cancer

Oral Cancer	Lip And Oral Cavity Carcinoma
Malignant Neoplasm Of Mouth

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Chronic Eosinophilic Leukemia

Pdgfra-Associated Chronic Eosinophilic Leukemia

Polycythemia

Erythrocythemia	Polycythemia Vera
Polycythaemia Due To High Altitude

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Acquired Polycythemia

Secondary Polycythemia	Polycythemia, Secondary
Secondary Erythrocytosis	Polycythemia Secondary

Aggressive Systemic Mastocytosis

Asm	Lymphadenopathic Mastocytosis With Eosinophilia

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Chronic Neutrophilic Leukemia

Cnl	Leukemia Neutrophilic Chronic

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Stress Polycythemia

Gaisbock'S Syndrome	Polycythemia, Emotional
Pseudopolycythaemia	Gaisboeck'S Syndrome
Pseudopolycythemia	Gaisbock Syndrome
Stress Erythrocytosis	Pseudo-Polycythemia
Relative Erythrocytosis

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Hypotrichosis 13

HYPT13	Hypotrichosis With Woolly Hair
Hypotrichosis, Type 13

Van Den Ende-Gupta Syndrome

VDEGS	Blepharophimosis, Arachnodactyly, And Congenital Contractures
Marden-Walker-Like Syndrome	Marden-Walker-Like Syndrome Without Psychomotor Retardation
Marden Walker Like Syndrome	Marden-Walker-Like Syndrome Without Psychmotor Retardation
Van Den Ende Gupta Syndrome	Marden Walker Like Syndrome Without Psychomotor Retardation
Blepharophimosis Arachnodactyly And Congenital Contractures

Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia	Acute Leukemia Of Ambiguous Lineage
Acute Undifferentiated Leukemia	Acute Leukemia Of Indeterminate Lineage
Hybrid Acute Leukemia	Mixed Lineage Acute Leukemia
All With Myeloid Markers	Aml With Lymphoid Markers
Acute Leukemia Of Undetermined Lineage	Bal
Biphenotypic Acute Leukemia	Undifferentiated Acute Leukemia
Mpal	Acute Myeloid Leukemia, Minimal Differentiation, Fab M0
Leukemia, Biphenotypic, Acute

B-Lymphoblastic Leukemia/Lymphoma With Iamp21

B-All With Iamp21

Intrachromosomal Amplification Of Chromosome 21

B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality

B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1

B-All With Bcr-Abl1	B-Lymphoblastic Leukemia/Lymphoma With T(9
22)(Q34.1	Q11.2)
Bcr-Abl1	B Lymphoblastic Leukemia/Lymphoma With T(9
22)(Q34.1	Q11.2)
Bcr-Abl1

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Cataract 36

CTRCT36	Catc4
Autosomal Recessive Congenital Cataract 4	Cataract, Autosomal Recessive Congenital 4
Cataract, Type 36

Lymphoblastic Leukemia, Acute, With Lymphomatous Features

LALL	Lymphomatous All
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia With Lymphomatous Features

Pectus Excavatum

Funnel Chest

Congenital Pectus Excavatum

Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic	Cmml
Leukemia Myelomonocytic Chronic	Cmml - [Chronic Myelomonocytic Leukaemia]
Chronic Myelomonocytic Leukaemia Without Mention Of Remission	Chronic Monocytic Leukaemia
Chronic Monocytoid Leukaemia

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

B-Cell Adult Acute Lymphocytic Leukemia

Adult B Acute Lymphoblastic Leukemia	Adult B Acute Lymphoblastic Leukaemia
Adult B-Cell Acute Lymphoblastic Leukaemia	Adult B-Cell Acute Lymphoblastic Leukemia
Adult B-Cell Lymphocytic Leukaemia	Adult B-Cell Lymphocytic Leukemia
Adult B-Lymphoblastic Leukaemia	Adult B-Lymphoblastic Leukemia
B-Cell Adult Acute Lymphocytic Leukaemia	B-Cell Adult Acute Lymphoblastic Leukemia

Esophageal Leukoplakia

Leukoplakia Of Esophagus

Chronic Leukemia

Adult Chronic Leukemia	Cll
Cml

Leiomyomatosis

B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma	B-All
Precursor B Lymphoblastic Lymphoma/Leukemia	C-All
Lymphoblastic Lymphoma, Nos	Common Precursor B All
Lymphoblastic B-Cell Lymphoma	Pro-B All
B-Precursor Lymphoma	Lbl - [Lymphoblastic Lymphoma]

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Blood Platelet Disease

Platelet Disorder	Blood Platelet Disorders
Thrombocytopathy	Platelet Dysfunction
Platelet Disorders	Qualitative Platelet Deficiency

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Hypereosinophilic Syndrome

Eosinophilia	HES
Eosinophilic Leukocytosis	Hypereosinophilic Syndrome, Idiopathic
Idiopathic Hypereosinophilic Syndrome	Disseminated Eosinophilic Collagen Disease
Eosinophilic Disorder	Disorders With Increased Eosinophil Counts

Congenital Heart Defects And Skeletal Malformations Syndrome

CHDSKM

Gastrointestinal Stromal Tumor

GIST	Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Sarcoma	Gastrointestinal Stromal Tumor, Familial
Gant	Gastrointestinal Stromal Tumour
Stromal Tumor Of Gastrointestinal Tract	Stromal Tumour Of Gastrointestinal Tract
Gastrointestinal Stromal Neoplasm	Paraganglioma And Gastric Stromal Sarcoma
Plexosarcoma

Central Nervous System Leukemia

Leukemia Of The Cns

Myelophthisic Anemia

Myelophthisis	Anemia Leukoerythroblastic
Anemia, Leukoerythroblastic	Leukoerythroblastosis
Anemia, Myelophthisic	Leukoerythroblastic Anemia

Childhood Leukemia

Testicular Leukemia

Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic	JMML
Leukemia, Juvenile Myelomonocytic, Somatic	Juvenile Chronic Myelomonocytic Leukemia
Juvenile Chronic Myelogenous Leukemia	Leukemia, Myelomonocytic, Juvenile
Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Childhood Acute Lymphocytic Leukemia

Childhood Acute Lymphoblastic Leukemia	Childhood All
Pediatric Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia Acute Childhood

Acute Myeloid Leukemia With Bcr-Abl1

Acute Myeleoid Leukemia With Bcr-Abl1

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104010	Asciminib	Inhibitor	99.88%	Yes
HY-15728	Radotinib		98.92%	Yes
HY-104010A	Asciminib hydrochloride	Inhibitor	99.84%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13024	Rebastinib		99.91%	Phase 2
HY-137460	Vodobatinib	Inhibitor	99.85%	Phase 2
HY-148794	Risvodetinib	Inhibitor	99.21%	Phase 2
HY-13072	Cenisertib	Inhibitor	99.86%	Phase 1

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-125834	GMB-475		98.98%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.34%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-W143698	PDGFRα kinase inhibitor 2	Inhibitor	≥98.0%	Unkown
HY-12338	ON 146040	Inhibitor	95.05%	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-107447S	N-Deshydroxyethyl Dasatinib-d8		/	Unkown
HY-101268	CHMFL-ABL-053	Inhibitor	/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-119177	PD173956	Inhibitor	/	Unkown
HY-130297	PROTAC BCR-ABL1 ligand 1	Inhibitor	/	Unkown
HY-145887	BCR-ABL1-IN-1		99.82%	Unkown
HY-14979	ML786	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-155112	Antiproliferative agent-30	Inhibitor	/	Unkown
HY-161445	(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH		/	Unkown
HY-162489	Tyrosine kinase-IN-8	Inhibitor	/	Unkown
HY-162952	cSRC/BCR-ABL1-IN-1	Inhibitor	/	Unkown
HY-18819	BCR-ABL-IN-2	Inhibitor	/	Unkown
HY-RS00102	ABL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00103	Abl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00104	ABL1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-13072B	Cenisertib benzoate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ABL1	VGNC	VGNC:69585
Mus musculus	ABL1	MGD	MGI:87859
Bos taurus	ABL1	VGNC	VGNC:50224
Felis catus	ABL1	VGNC	VGNC:68393
Canis familiaris	ABL1	VGNC	VGNC:54912
Rattus norvegicus	ABL1	RGD	RGD:1584969
Others	ABL1	NCBI