2. Gene
  3. HLA-F - major histocompatibility complex, class I, F Gene

HLA-F - major histocompatibility complex, class I, F Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HLAF; CDA12; HLA-5.4; HLA-CDA12

Gene ID: 3134 | Gene type: protein coding

About HLA-F

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:29,723,434-29,738,532 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 586 orthologues and 22 paralogues. Broad expression in spleen (RPKM 31.0), lymph node (RPKM 20.6) and 24 other tissues.

Summary

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most Other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of Peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from Other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]

HLA-F Products(3)

mRNA Protein Name
NM_001098478.2 NP_001091948.1 HLA class I histocompatibility antigen, alpha chain F isoform 3 precursor
NM_001098479.2 NP_001091949.1 HLA class I histocompatibility antigen, alpha chain F isoform 1 precursor
NM_018950.3 NP_061823.2 HLA class I histocompatibility antigen, alpha chain F isoform 2 precursor

HLA-F Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (22 - 200)

C1-set

C1-set: Immunoglobulin C1-set domain (216 - 291)

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  • 346 a.a.
Protein Preferred Names Protein Names

HLA class I histocompatibility antigen, alpha chain F

HLA F antigen

HLA-F Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HLA-F P30511 KIR3DS1 Homo sapiens Q14943
Affinity Techniques
27455421
Intra
HLA-F P30511 KIR3DS1 Homo sapiens Q14943
SPR
27455421
Intra
HLA-F P30511 KIR3DL1 Homo sapiens P43629
SPR
27455421
Intra
HLA-F P30511 KIR3DL1 Homo sapiens P43629
Affinity Techniques
27455421
Intra
HLA-F P30511 KIR3DL2 Homo sapiens P43630
SPR
27455421
Intra
HLA-F P30511 KIR3DL2 Homo sapiens P43630
Affinity Techniques
27455421
Intra
HLA-F P30511 HLA-E Homo sapiens P13747
Anti Bait CoIP
20483783
Intra
HLA-F P30511 HLA-E Homo sapiens P13747
SPR
20483783
Cross: Cross-species interaction Intra: Intraspecies interaction

HLA-F Antibodies

Cat. No. Product Name Application Reactivity
HY-P83098 HLA F Antibody (YA2843) WB, IHC-P Human

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06216 HLA-F Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-F RGD RGD:1595868