2. Gene
  3. Ski - Ski proto-oncogene Gene

Ski - Ski proto-oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as c-ski; RGD1565591

Gene ID: 313757 | Gene type: protein coding

About Ski

Summary

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; Enzyme binding activity; and histone deacetylase inhibitor activity. Predicted to be involved in several processes, including SMAD protein signal transduction; negative regulation of osteoblast differentiation; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; face morphogenesis; and nervous system development. Predicted to be located in PML body; centrosome; and cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Ski Products(2)

mRNA Protein Name
XM_039111374.1 XP_038967302.1 ski oncogene isoform X2
XM_017593893.2 XP_017449382.2 ski oncogene isoform X1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cardiac muscle cell proliferation IEP
IEP: Inferred from expression pattern
2447874 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ski oncogene

Sloan-Kettering viral oncogene homolog

ski sarcoma viral oncogene homolog

v-ski avian sarcoma viral oncogene homolog

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10158 Bosutinib 99.96% Yes
HY-10158A Bosutinib hydrate Inhibitor 99.97% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13822 SKI II 99.78% Unkown
HY-12892 SKI-178 98.91% Unkown
HY-18366A RU-SKI 43 hydrochloride Inhibitor 99.55% Unkown
HY-109082A Cevidoplenib dimesylate Inhibitor 98.96% Unkown
HY-115735 SKI-I 99.14% Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-10158S Bosutinib-d8 ≥99.0% Unkown
HY-12895 SKI V 98.95% Unkown
HY-162143 SKI-349 Inhibitor 99.58% Unkown
HY-106588 Heptaplatin / Unkown
HY-117563 CAY10621 Inhibitor / Unkown
HY-161441 SIK-IN-2 Inhibitor / Unkown
HY-161442 SIK-IN-3 Inhibitor / Unkown
HY-19325 SKI2852 Inhibitor 98.33% Unkown
HY-RS12969 SKI Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-10158AR Bosutinib (hydrate) (Standard) Inhibitor / Unkown
HY-114206 SKI-73 / Unkown
HY-117982 SKI2496 / Unkown
HY-W714171 Propoxycarbazone sodium / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ski NCBI NCBI:6497
Macaca fascicularis Ski NCBI NCBI:102144358
Mus musculus Ski NCBI NCBI:20481