2. Immunology/Inflammation PI3K/Akt/mTOR
  3. SphK Akt mTOR
  4. SKI-349

SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells.

For research use only. We do not sell to patients.

SKI-349 Chemical Structure

SKI-349 Chemical Structure

CAS No. : 727686-80-8

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5 mg USD 100 In-stock
10 mg USD 160 In-stock
25 mg USD 320 In-stock
50 mg USD 500 In-stock
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Based on 1 publication(s) in Google Scholar

SKI-349 Related Antibodies

Top Publications Citing Use of Products

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SphK1 SphK2

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Akt Akt1 Akt2 Akt3

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mTOR mTORC1 mTORC2

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Description

SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells[1][2].

Molecular Weight

385.44

Formula

C19H19N3O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=C(C(OC)=C3)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (324.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5944 mL 12.9722 mL 25.9444 mL
5 mM 0.5189 mL 2.5944 mL 5.1889 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5944 mL 12.9722 mL 25.9444 mL 64.8609 mL
5 mM 0.5189 mL 2.5944 mL 5.1889 mL 12.9722 mL
10 mM 0.2594 mL 1.2972 mL 2.5944 mL 6.4861 mL
15 mM 0.1730 mL 0.8648 mL 1.7296 mL 4.3241 mL
20 mM 0.1297 mL 0.6486 mL 1.2972 mL 3.2430 mL
25 mM 0.1038 mL 0.5189 mL 1.0378 mL 2.5944 mL
30 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1620 mL
40 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6215 mL
50 mM 0.0519 mL 0.2594 mL 0.5189 mL 1.2972 mL
60 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0810 mL
80 mM 0.0324 mL 0.1622 mL 0.3243 mL 0.8108 mL
100 mM 0.0259 mL 0.1297 mL 0.2594 mL 0.6486 mL
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SKI-349 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKI-349727686-80-8SKI349SKI 349SphKAktmTORSphingosine kinasePKBProtein kinase BMammalian target of RapamycinHepatocellular carcinoma (HCC)liver cellsanticancerAKT/mTORInhibitorinhibitorinhibit

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