HLX - H2.0 like homeobox Gene

Homo sapiens

Also known as HB24; HLX1

Gene ID: 3142 | Gene type: protein coding

About HLX

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,879,443-220,885,059 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 18.6), fat (RPKM 10.7) and 19 other tissues.

Summary

Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

HLX Products(1)

mRNA	Protein	Name
NM_021958.4	NP_068777.1	H2.0-like homeobox protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9073066	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLX Protein Structure

Homeobox

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

H2.0-like homeobox protein

H2.0-like homeo box-1

HLX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HLX	Q14774	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	HLX	Q14774	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	HLX	Q14774	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	HLX	Q14774	MIEN1	Homo sapiens	Q9BRT3	Validated Y2H	32296183
Intra	HLX	Q14774	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	HLX	Q14774	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diaphragmatic Hernia-Short Bowel-Asplenia Syndrome

Diaphragmatic Eventration

Osteogenesis Imperfecta, Type Xi

Osteogenesis Imperfecta Type 11	OI11
Osteogenesis Imperfecta Type Xi	Oi, Type Xi
Osteogenesis Imperfecta 11	Oi Type Xi
Oi-Xi

Diaphragm Disease

Abnormality Of The Diaphragm	Disease Of Diaphragm
Diaphragmatic Disorder	Disorder Of Diaphragm

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia	Diaphragmatic Hernia
Cdh	Congenital Diaphragmatic Defect
Hernia, Diaphragmatic	Dih
Hernia, Congenital Diaphragmatic	Hcd
Diaphragmatic Defect, Congenital	Diaphragm, Unilateral Agenesis Of
Hemidiaphragm, Agenesis Of	Diaphragmatic Hernia 1
Agenesis Of Hemidiaphragm	Unilateral Agenesis Of Diaphragm
Hernia Diaphragmatic	Hernia Diaphragmatic Congenital
Hernia, Diaphragmatic, Type 1	Hiatus Hernia
Oesophageal Hiatus Hernia	Paraoesophageal Hernia
Sliding Hiatus Hernia	Congenital Diaphragm Hernia
Congenital Diaphragm Defect With Hernia	Gross Congenital Diaphragm Defect

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99118	Serplulimab	Inhibitor	99.30%	Unkown

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99785	Opucolimab	Inhibitor	/	Phase 1
HY-P99516	Vulinacimab	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06221	HLX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HLX	MGD	MGI:96109
Macaca mulatta	HLX	VGNC	VGNC:106382
Canis familiaris	HLX	VGNC	VGNC:50302
Rattus norvegicus	HLX	RGD	RGD:1311961
Bos taurus	HLX	VGNC	VGNC:50277
Felis catus	HLX	VGNC	VGNC:107879

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