2. Gene
  3. MIEN1 - migration and invasion enhancer 1 Gene

MIEN1 - migration and invasion enhancer 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C35; ORB3; XTP4; RDX12; C17orf37

Gene ID: 84299 | Gene type: protein coding

About MIEN1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,728,510-39,730,532 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 15.4), esophagus (RPKM 14.3) and 25 other tissues.

Summary

Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is intrinsic component of the cytoplasmic side of the plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MIEN1 Products(2)

mRNA Protein Name
NM_001330206.2 NP_001317135.1 migration and invasion enhancer 1 isoform 2
NM_032339.5 NP_115715.3 migration and invasion enhancer 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
21068479 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
21628459 GOA
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
21628459 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
21628459 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21628459 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIEN1 Protein Structure

Rdx

Rdx: Rdx family (24 - 95)

  • 0
  • 100
  • 115 a.a.
Protein Preferred Names Protein Names

migration and invasion enhancer 1

HBV X-transactivated gene 4 protein

MIEN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MIEN1 Q9BRT3 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Array
32296183
Intra MIEN1 Q9BRT3 ZBTB32 Homo sapiens A0A0C4DGF1
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 VENTX Homo sapiens O95231
Y2H Array
32296183
Intra MIEN1 Q9BRT3 VENTX Homo sapiens O95231
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra MIEN1 Q9BRT3 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra MIEN1 Q9BRT3 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 HDAC7 Homo sapiens Q8WUI4-6
Y2H Array
32296183
Intra MIEN1 Q9BRT3 HDAC7 Homo sapiens Q8WUI4-6
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra MIEN1 Q9BRT3 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra MIEN1 Q9BRT3 HLX Homo sapiens Q14774
Y2H Array
32296183
Intra MIEN1 Q9BRT3 HLX Homo sapiens Q14774
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra MIEN1 Q9BRT3 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra MIEN1 Q9BRT3 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra MIEN1 Q9BRT3 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra MIEN1 Q9BRT3 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra MIEN1 Q9BRT3 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Large Cell Neuroendocrine Carcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08441 MIEN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MIEN1 VGNC VGNC:63499
Mus musculus MIEN1 MGD MGI:1913678
Bos taurus MIEN1 VGNC VGNC:31468
Rattus norvegicus MIEN1 RGD RGD:1306682
Canis familiaris MIEN1 VGNC VGNC:43228