Mdm2 - MDM2 proto-oncogene Gene

Rattus norvegicus

Gene ID: 314856 | Gene type: protein coding

About Mdm2

Primary_assembly 7: 53,290,664-53,314,915 reverse strand.mRatBN7.2:CM026980.1

This gene has 4 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 41 phenotypes. Biased expression in Testes (RPKM 24.7), Muscle (RPKM 22.2) and 9 other tissues.

Summary

Enables p53 binding activity; signaling receptor binding activity; and ubiquitin protein Ligase activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of proteolysis; and response to alkaloid. Located in several cellular components, including cytosol; nucleus; and synapse. Used to study ichthyosis; post-traumatic stress disorder; and transient cerebral ischemia. Biomarker of breast cancer; intermittent claudication; liver disease; pancreatitis; and priapism. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; glioblastoma; hepatocellular carcinoma; pancreatic ductal carcinoma; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Mdm2 Products(1)

mRNA	Protein	Name
NM_001108099.1	NP_001101569.1	E3 ubiquitin-protein ligase Mdm2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables p53 binding	IPI IPI: Inferred from physical interaction	16330492	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	19103650	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14642282	RGD
enables receptor serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	26228571	RGD
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	14642282	RGD
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	16330492	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV-C	IEP IEP: Inferred from expression pattern	14558917	RGD
involved in cellular response to alkaloid	IEP IEP: Inferred from expression pattern	19136059	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	18469520	RGD
involved in cellular response to estrogen stimulus	IEP IEP: Inferred from expression pattern	14667141	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	16091747	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	19638633	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19819240	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	19850968	RGD
involved in cellular response to vitamin B1	IEP IEP: Inferred from expression pattern	15656374	RGD
involved in fibroblast activation	IMP IMP: Inferred from mutant phenotype	28100501	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19103650	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17881359	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19850968	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19850968	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23051735	RGD
involved in negative regulation of protein processing	IMP IMP: Inferred from mutant phenotype	19638633	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19103650	RGD
involved in positive regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	17881359	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	21498419	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21498419	RGD
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14642282	RGD
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	16330492	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	14642282	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	14642282	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	14642282	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	EXP EXP: Inferred from Experiment	14642282	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IDA IDA: Inferred from direct assay	14642282	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	14642282	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	14625023	RGD
involved in response to ether	IEP IEP: Inferred from expression pattern	16790648	RGD
involved in response to formaldehyde	IEP IEP: Inferred from expression pattern	18045764	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	20019189	RGD
involved in response to magnesium ion	IEP IEP: Inferred from expression pattern	15165363	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	17000718	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	16598789	RGD
involved in response to water-immersion restraint stress	IDA IDA: Inferred from direct assay	23174211	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19136059	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	14642282	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14642282	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	14642282	RGD
is active in postsynaptic density	EXP EXP: Inferred from Experiment	21849563	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21849563	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mdm2 Protein Structure

MDM2

zf-RanBP

mRING-HC-C2H2C4_MDM2

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532 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Mdm2

MDM2 oncogene, E3 ubiquitin protein ligase	MDM2 proto-oncogene, E3 ubiquitin protein ligase
Mdm2 p53 binding protein homolog	double minute 2
p53 E3 ubiquitin protein ligase	transformed mouse 3T3 cell double minute 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128837	Nutlin carboxylic acid		98.63%	Unkown
HY-128836	(4R,5S)-Nutlin carboxylic acid		/	Unkown
HY-168280	AS1411-C4-VH032	Degrader	/	Unkown
HY-P5930	HOXB7 8–25		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mdm2	NCBI	NCBI:4193

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