2. PROTAC
  3. Ligands for E3 Ligase
  4. (4R,5S)-Nutlin carboxylic acid

(4R,5S)-Nutlin carboxylic acid  (Synonyms: MDM2 ligand 2; E3 ligase Ligand 15)

Cat. No.: HY-128836
Handling Instructions

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(4R,5S)-Nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs.

For research use only. We do not sell to patients.

(4R,5S)-Nutlin carboxylic acid Chemical Structure

(4R,5S)-Nutlin carboxylic acid Chemical Structure

CAS No. : 2306390-08-7

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Other Forms of (4R,5S)-Nutlin carboxylic acid:

(4R,5S)-Nutlin carboxylic acid Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

(4R,5S)-Nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target

MDM2

 

Molecular Weight

639.53

Formula

C32H32Cl2N4O6
CAS No.
SMILES

O=C1N(CC(O)=O)CCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(4R,5S)-Nutlin carboxylic acid Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(4R,5S)-Nutlin carboxylic acid2306390-08-7MDM2 ligand 2 E3 ligase Ligand 15Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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