HRG - histidine rich glycoprotein Gene

Homo sapiens

Also known as HPRG; HRGP; THPH11

Gene ID: 3273 | Gene type: protein coding

About HRG

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,666,014-186,678,234 (from NCBI)

This gene has 3 transcripts (splice variants), 118 orthologues, 3 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 1677.7).

Summary

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

HRG Products(1)

mRNA	Protein	Name
NM_000412.5	NP_000403.1	histidine-rich glycoprotein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heme binding	IDA IDA: Inferred from direct assay	678554	GOA
enables heparan sulfate proteoglycan binding	IDA IDA: Inferred from direct assay	15138272	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	16436387	GOA
enables immunoglobulin binding	IDA IDA: Inferred from direct assay	10514432	GOA
enables metal ion binding	IDA IDA: Inferred from direct assay	678554	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11134179	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	16436387	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15138272	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	18797515	GOA
involved in cytolysis by host of symbiont cells	IDA IDA: Inferred from direct assay	18797515	GOA
involved in defense response to fungus	IDA IDA: Inferred from direct assay	18797515	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	14744774	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	14744774	GOA
involved in negative regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	16489009	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	21215706	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	14744774	GOA
involved in negative regulation of endothelial cell chemotaxis	IDA IDA: Inferred from direct assay	14744774	GOA
involved in negative regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	16489009	GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway	IDA IDA: Inferred from direct assay	16489009	GOA
involved in platelet activation	IDA IDA: Inferred from direct assay	19903770	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	14744774	GOA
involved in positive regulation of blood vessel remodeling	IDA IDA: Inferred from direct assay	21215706	GOA
involved in positive regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	14744774	GOA
involved in positive regulation of immune response to tumor cell	IDA IDA: Inferred from direct assay	21215706	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	16489009	GOA
involved in regulation of blood coagulation	IDA IDA: Inferred from direct assay	6740558	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	21215706	GOA
involved in regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	16489009	GOA
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	16489009	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15220341	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	18797515	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HRG Protein Structure

Cystatin

0
100
200
300
400
525 a.a.

Protein Preferred Names

Protein Names

histidine-rich glycoprotein

histidine-proline-rich glycoprotein

HRG Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HRG	P04196	RGS20	Homo sapiens	O76081-6	Y2H Prey Pooling	32296183
Intra	HRG	P04196	RGS20	Homo sapiens	O76081-6	Y2H Array	32296183
Intra	HRG	P04196	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	HRG	P04196	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Cross	HRG	P04196	q99xu0_strp1	Streptococcus pyogenes serotype M1	Q99XU0	ITC	24825900
Intra	HRG	P04196	RCHY1	Homo sapiens	Q96PM5	Confocal	21988832
Intra	HRG	P04196	RCHY1	Homo sapiens	Q96PM5	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HRG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77380	HPRG Protein, Human (HEK293, His)	P04196/NP_000403.1 (V19-K525)	≥95%

Related Diseases

Diseases

Alias

Thrombophilia Due To Histidine-Rich Glycoprotein Deficiency

THPH11

Thrombophilia 11 Due To Hrg Deficiency

Thrombophilia Due To Hrg Deficiency

Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency	Hereditary Thrombophilia Due To Congenital Hrg Deficiency
Thph11

Thrombophilia

Hypercoagulability State

Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency	Proc Deficiency
Congenital Thrombotic Disease, Due To Protein C Deficiency

Thrombosis

Thrombosis Of Blood Vessel

Prothrombin Thrombophilia

Prothrombin G20210a Thrombophilia

Hyperprothrombinemia

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Corneal Neovascularization

Corneal Neovascularisation	Corneal Vascularisation
Extensive Superficial Corneal Vascularisation

Plasminogen Deficiency, Type I

Hypoplasminogenemia	Dysplasminogenemia
Plasminogen Deficiency Type I	Congenital Plasminogen Deficiency
Ligneous Conjunctivitis	Type 1 Plasminogen Deficiency
Plasminogen Deficiency Type 1	Plasminogen Deficiency
PLGD	Plasminogen Deficiency Type Ii
Deficiency, Plasminogen, Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06358	HRG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HRG	MGD	MGI:2146636
Rattus norvegicus	HRG	RGD	RGD:619808
Macaca mulatta	HRG	VGNC	VGNC:73521
Canis familiaris	HRG	VGNC	VGNC:41785
Felis catus	HRG	VGNC	VGNC:67648
Bos taurus	HRG	VGNC	VGNC:29953
Others	HRG	NCBI

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