HSPA1B - heat shock protein family A (Hsp70) member 1B Gene

Homo sapiens

Also known as HSP72; HSPA1; HSX70; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1B

Gene ID: 3304 | Gene type: protein coding

About HSPA1B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,827,738-31,830,254 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 142 orthologues and 13 paralogues.

Summary

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with Other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

HSPA1B Products(1)

mRNA	Protein	Name
NM_005346.6	NP_005337.2	heat shock 70 kDa protein 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	23921388	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	21231916	GOA
enables ATP-dependent protein disaggregase activity	IDA IDA: Inferred from direct assay	23921388	GOA
enables C3HC4-type RING finger domain binding	IPI IPI: Inferred from physical interaction	25281747	GOA
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	12150907	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	17182002	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16809764	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9553041	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	15603737	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	24790089	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ATP metabolic process	IDA IDA: Inferred from direct assay	23921388	GOA
involved in cellular heat acclimation	IMP IMP: Inferred from mutant phenotype	21231916	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	24061851	GOA
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	10205060	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	9553041	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9553041	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in negative regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	15603737	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	12150907	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17167422	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25281747	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of microtubule nucleation	IMP IMP: Inferred from mutant phenotype	27137183	GOA
involved in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in protein refolding	IDA IDA: Inferred from direct assay	15603737	GOA
involved in protein refolding	IMP IMP: Inferred from mutant phenotype	27708256	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	27137183	GOA
involved in regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16809764	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in aggresome	IDA IDA: Inferred from direct assay	15885686	GOA
located in centriole	IDA IDA: Inferred from direct assay	24061851	GOA
located in centrosome	IDA IDA: Inferred from direct assay	27137183	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9553041	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	15603737	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	9553041	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10205060	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10205060	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA1B Protein Structure

HSP70

0
100
200
300
400
500
600
641 a.a.

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 1B

HSP70-1/HSP70-2

HSPA1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPA1B	P0DMV9	F2RL1	Homo sapiens	P55085	Anti Bait CoIP	28298427
Intra	HSPA1B	P0DMV9	F2RL1	Homo sapiens	P55085	Ub Reconstruction	28298427

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSPA1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73105	HSP70/HSPA1B Protein, Human (SF9, His)	P0DMV9/NP_005337.2 (A2-D641)	≥95%
HY-P74877	HSP70/HSPA1A Protein, Human (HEK293, His)	P0DMV8-1/NP_005336.3 (A2-D641)	≥95%
HY-P701004	HSP70/HSPA1A Protein, Human (E110D, His)	P0DMV8-1 (A2-D641, E110D)	≥95%

Related Diseases

Diseases

Alias

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06425	HSPA1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HSPA1B	RGD	RGD:2840
Mus musculus	HSPA1B	MGD	MGI:99517

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