Il1rapl1 - interleukin 1 receptor accessory protein-like 1 Gene

Mus musculus

Also known as IL1R8; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; C030039N24; 6330532G10Rik

Gene ID: 331461 | Gene type: protein coding

About Il1rapl1

Summary

Enables signaling receptor binding activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; nervous system development; and positive regulation of nervous system development. Located in cell surface and dendrite. Is expressed in central nervous system; dorsal root ganglion; eye; lung; and trigeminal nerve. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1). [provided by Alliance of Genome Resources, Apr 2022]

Il1rapl1 Products(1)

mRNA	Protein	Name
NM_001160403.2	NP_001153875.1	interleukin-1 receptor accessory protein-like 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21940441	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	21940441	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	21940441	MGI
involved in neuron differentiation	IDA IDA: Inferred from direct assay	21940441	MGI
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	21940441	MGI
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21940441	MGI
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	25908590	MGI
involved in presynaptic membrane assembly	IMP IMP: Inferred from mutant phenotype	21940441	MGI
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	21940441	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	21940441	MGI
located in dendrite	IDA IDA: Inferred from direct assay	21940441	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-1 receptor accessory protein-like 1

X-linked interleukin-1 receptor accessory protein-like 1

Recombinant Il1rapl1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76998	IL1RAPL1 Protein, Mouse (HEK293, Fc)	P59823 (R25-T357)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06723	IL1RAPL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il1rapl1	NCBI	NCBI:11141

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