HTR7 - 5-hydroxytryptamine receptor 7 Gene

Homo sapiens

Also known as 5-HT7

Gene ID: 3363 | Gene type: protein coding

About HTR7

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:90,740,823-90,858,039 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues and 8 paralogues. Biased expression in testis (RPKM 6.1), urinary bladder (RPKM 2.0) and 8 other tissues.

Summary

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

HTR7 Products(4)

mRNA	Protein	Name
NM_019860.4	NP_062874.1	5-hydroxytryptamine receptor 7 isoform b
XM_024447973.2	XP_024303741.1	5-hydroxytryptamine receptor 7 isoform X1
NM_000872.5	NP_000863.1	5-hydroxytryptamine receptor 7 isoform a
NM_019859.4	NP_062873.1	5-hydroxytryptamine receptor 7 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	8226867	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19486527	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	8226867	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	22448645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR7 Protein Structure

7tm_1

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 7

5-HT-7	5-HT-X
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Severe Congenital Neutropenia 8

Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities	Scn8
Sdsl	Shwachman-Diamond Syndrome-Like

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Hymenolepiasis

Dwarf Tapeworm Infection	Hymenolepis Infectious Disease
Hymenolepsis Infection	Hyemolepis Nana Infection
Hymenolepiosis	Hymenolepis Infection
Dwarf Tapeworm	Hymenolepidosis
Hymenolepis Infestation

Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma

Oculogyric Crisis

Mental Depression

Depression

Depressive Disorder

Ischemic Colitis

Colitis, Ischemic

Irreversible Ischaemic Colitis

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06483	HTR7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06484	Htr7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06485	HTR7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HTR7	VGNC	VGNC:30003
Rattus norvegicus	HTR7	RGD	RGD:71034
Mus musculus	HTR7	MGD	MGI:99841
Macaca mulatta	HTR7	VGNC	VGNC:106061
Felis catus	HTR7	VGNC	VGNC:67677
Canis familiaris	HTR7	VGNC	VGNC:41834

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