TNC - tenascin C Gene

Homo sapiens

Also known as GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225

Gene ID: 3371 | Gene type: protein coding

About TNC

Cytogenetic location: 9q33.1 Genomic coordinates (GRCh38): 9:115,019,575-115,118,157 (from NCBI)

This gene has 15 transcripts (splice variants), 200 orthologues, 25 paralogues and is associated with 90 phenotypes. Broad expression in appendix (RPKM 76.9), endometrium (RPKM 19.4) and 15 other tissues.

Summary

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

TNC Products(2)

mRNA	Protein	Name
NM_001410991.1	NP_001397920.1	tenascin isoform 2 precursor
NM_002160.4	NP_002151.2	tenascin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IDA IDA: Inferred from direct assay	22654117	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20979576	GOA
enables syndecan binding	IDA IDA: Inferred from direct assay	8769660	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	11731446	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	11731446	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	16891397	GOA
involved in response to wounding	IEP IEP: Inferred from expression pattern	16891397	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	23658023	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNC Protein Structure

hEGF

EGF_2

hEGF

EGF_2

hEGF

fn3

Fibrinogen_C

0
400
800
1200
1600
2000
2201 a.a.

Protein Preferred Names

Protein Names

tenascin

GP 150-225

TNC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNC	P24821	COL5A1	Homo sapiens	P20908	Y2H	20979576
Intra	TNC	P24821	TLR4	Homo sapiens	O00206	ELISA	29150600

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71691	TNC Protein, Human (His)	P24821-1 (D1888-A2201)	≥95%
HY-P700833	Tenascin/Tnc protein, Human (HEK293, His)	P24821-1 (G23-S621)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 56

DFNA56	Autosomal Dominant Nonsyndromic Deafness 56
Autosomal Dominant Deafness 56	Deafness, Autosomal Dominant, 56
Deafness, Autosomal Dominant, Type 56

Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Isolated Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna	Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna

Bullous Keratopathy

Bk - [Bullous Keratopathy]

Acute Myocarditis

Glioma

Juvenile Pilocytic Astrocytoma

Cryptogenic Organizing Pneumonia

Bronchiolitis Obliterans Organizing Pneumonia	Boop
Constrictive Bronchiolitis	Cryptogenic Organizing Pneumonitis
Cop	Bronchiolitis Obliterans Organising Pneumonia
Cryptogenic Organising Pneumonia	Cryptogenic Organising Pneumonitis
Idiopathic Bronchiolitis Obliterans With Organising Pneumonia	Idiopathic Bronchiolitis Obliterans With Organizing Pneumonia
Organizing Pneumonia	Idiopathic Boop
Idiopathic Bronchiolitis Obliterans Organizing Pneumonia	Organized Pneumonia

Tendinopathy

Tarsal Tunnel Syndrome

Neuropathy Of The Posterior Tibial Nerve And Its Branches	Posterior Tibial Nerve Neuralgia
Compression Of Posterior Tibial Nerve In Tarsal Tunnel

Tibial Neuropathy

Posterior Tibial Neuropathy

Dentinogenesis Imperfecta

Hereditary Opalescent Dentin	Dentinogenesis Imperfecta Without Osteogenesis Imperfecta
Dgi	Capdepont Teeth
Dgi Without Oi	Di
Non-Syndromic Dgi	Non-Syndromic Dentinogenesis Imperfecta
Opalescent Teeth Without Oi	Opalescent Teeth Without Osteogenesis Imperfecta
Opalescent Dentin

Interstitial Pneumonitis, Desquamative, Familial

Desquamative Interstitial Pneumonia	DIP
Pneumonitis, Desquamative Interstitial, Familial	Pneumonia, Desquamative Interstitial, Familial
Interstitial Lung Disease, Desquamative	Ild, Desquamative
Familial Desquamative Interstitial Pneumonitis	Rbild
Respiratory Bronchiolitis-Associated Interstitial Lung Disease	Respiratory Bronchiolitis Associated Interstitial Lung Disease

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Merkel Cell Carcinoma

Trabecular Adenocarcinoma	Cutaneous Neuroendocrine Carcinoma
Trabecular Carcinoma	Carcinoma, Merkel Cell
Merkel Cell Cancer	Merkle Tumors
Mcc	Carcinoma Merkel Cell

Sialadenitis

Sialoadenitis	Adenitis, Salivary Gland
Salivary Gland Inflammation	Salivary Gland Adenitis
Sialitis	Inflammation Of Salivary Gland
Inflammation Of Salivary Duct Or Gland	Salivary Glandular Adenitis
Sialoangiitis	Sialoangitis
Sialodochitis

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Breast Disease

Breast Diseases

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14783	TNC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNC	RGD	RGD:621057
Bos taurus	TNC	VGNC	VGNC:36152
Mus musculus	TNC	MGD	MGI:101922
Macaca mulatta	TNC	VGNC	VGNC:79960
Canis familiaris	TNC	VGNC	VGNC:47646
Felis catus	TNC	VGNC	VGNC:67678
Others	TNC	NCBI

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