ARSI - arylsulfatase family member I Gene

Homo sapiens

Also known as ASI; SPG66

Gene ID: 340075 | Gene type: protein coding

About ARSI

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,296,343-150,302,905 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues, 16 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 1.9), placenta (RPKM 1.8) and 20 other tissues.

Summary

This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]

ARSI Products(1)

mRNA	Protein	Name
NM_001012301.4	NP_001012301.1	arylsulfatase I precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARSI Protein Structure

Sulfatase

0
100
200
300
400
500
569 a.a.

Protein Preferred Names

Protein Names

arylsulfatase I

ARSI Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARSI	Q5FYB1	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Recessive Spastic Paraplegia Type 66

Spg66

Spastic Paraplegia 63, Autosomal Recessive

SPG63	Hereditary Spastic Paraplegia 63
Spastic Paraplegia 63	Autosomal Recessive Spastic Paraplegia 63
Autosomal Recessive Spastic Paraplegia Type 63	Paraplegia, Spastic, Type 63, Autosomal Recessive

Noonan Syndrome 8

NS8	Noonan Syndrome, Type 8

Spastic Paraplegia 78, Autosomal Recessive

SPG78	Autosomal Recessive Spastic Paraplegia Type 78
Hereditary Spastic Paraplegia 78	Spastic Paraplegia 78 Autosomal Recessive
Doid:0112348

Gastric Dilatation

Stomach Dilatation

Alternating Exotropia

Exotropia

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01040	ARSI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARSI	MGD	MGI:2670959
Rattus norvegicus	ARSI	RGD	RGD:1310242
Canis familiaris	ARSI	VGNC	VGNC:38144
Macaca mulatta	ARSI	VGNC	VGNC:69937
Bos taurus	ARSI	VGNC	VGNC:26177
Felis catus	ARSI	VGNC	VGNC:59948

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