ZC3H12D - zinc finger CCCH-type containing 12D Gene

Homo sapiens

Also known as TFL; p34; MCPIP4; C6orf95; dJ281H8.1

Gene ID: 340152 | Gene type: protein coding

About ZC3H12D

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,446,795-149,485,014 (from NCBI)

This gene has 5 transcripts (splice variants), 128 orthologues and 6 paralogues. Biased expression in lymph node (RPKM 4.6), appendix (RPKM 3.5) and 11 other tissues.

Summary

Predicted to enable endoribonuclease activity and mRNA binding activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and negative regulation of cell growth. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZC3H12D Products(1)

mRNA	Protein	Name
NM_207360.3	NP_997243.2	probable ribonuclease ZC3H12D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26134560	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	19531561	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	19531561	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	24415781	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19531561	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19531561	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZC3H12D Protein Structure

RNase_Zc3h12a

0
100
200
300
400
527 a.a.

Protein Preferred Names

Protein Names

probable ribonuclease ZC3H12D

Zinc finger CCCH domain-containing protein 12D

Related Diseases

Diseases

Alias

Follicular Lymphoma

Lymphoma, Follicular	Lymphoma Follicular
Brill-Symmers' Disease	Large Cell Follicular Non-Hodgkin Lymphoma
Diffuse Follicle Centre Lymphoma	Diffuse Follicular Lymphoma Nos
Follicular Nodular Non-Hodgkin Lymphoma, Unspecified	Follicular Large Cell Cleaved Or Noncleaved Lymphoma
Large Cell Follicular Noncleaved Lymphoma	Follicular Lymphoma With Or Without Diffuse Areas
Histiocytic Follicular Lymphoma	Histiocytic Nodular Lymphoma
Histiocytic Nodular Malignant Lymphoma	Large Cell Follicular Lymphoma
Large Cell Noncleaved Follicular Lymphoma	Large Cell Noncleaved Follicular Malignant Lymphoma
Nodular Reticulum Cell Sarcoma	Noncleaved Follicular Lymphoma

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Eastern Equine Encephalitis

Eee	Neuroinvasive Eastern Equine Encephalitis Virus Infection
Eastern Equine Encephalomyelitis	Encephalomyelitis, Eastern Equine
Triple E	Eastern Equine Encephalitis Virus Infection
Neuroinvasive Eastern Equine Encephalitis Virus Disease	Eee - [Eastern Equine Encephalitis]

Drug-Induced Lupus Erythematosus

Dile	Dil
Drug-Induced Systemic Lupus Erythematosus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15987	ZC3H12D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZC3H12D	VGNC	VGNC:102555
Bos taurus	ZC3H12D	VGNC	VGNC:37100
Canis familiaris	ZC3H12D	VGNC	VGNC:54006
Macaca mulatta	ZC3H12D	VGNC	VGNC:83972
Mus musculus	ZC3H12D	MGD	MGI:3045313
Rattus norvegicus	ZC3H12D	RGD	RGD:1597152

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