VSIG1 - V-set and immunoglobulin domain containing 1 Gene

Homo sapiens

Also known as GPA34; dJ889N15.1; 1700062D20Rik

Gene ID: 340547 | Gene type: protein coding

About VSIG1

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,018,879-108,079,184 (from NCBI)

This gene has 5 transcripts (splice variants), 164 orthologues and 14 paralogues. Biased expression in stomach (RPKM 88.2), testis (RPKM 34.6) and 1 other tissue.

Summary

This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

VSIG1 Products(2)

mRNA	Protein	Name
NM_001170553.2	NP_001164024.1	V-set and immunoglobulin domain-containing protein 1 isoform 1 precursor
NM_182607.5	NP_872413.1	V-set and immunoglobulin domain-containing protein 1 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSIG1 Protein Structure

V-set

Ig_2

0
100
200
300
387 a.a.

Protein Preferred Names

Protein Names

V-set and immunoglobulin domain-containing protein 1

cell surface A33 antigen

VSIG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VSIG1	Q86XK7	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VSIG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71675	VSIG1 Protein, Human (HEK293, His)	Q86XK7-1 (V22-E232)	≥95%

Related Diseases

Diseases

Alias

Mucinous Lung Adenocarcinoma

Ovarian Cystadenoma

Cystoma Serosum Simplex	Simple Cystoma Of Ovary
Simple Cystoma Of The Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15706	VSIG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VSIG1	MGD	MGI:1926039
Canis familiaris	VSIG1	VGNC	VGNC:54610
Bos taurus	VSIG1	VGNC	VGNC:56959
Rattus norvegicus	VSIG1	RGD	RGD:1565570
Felis catus	VSIG1	VGNC	VGNC:66976
Macaca mulatta	VSIG1	VGNC	VGNC:79734
Others	VSIG1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.