NANOS1 - nanos C2HC-type zinc finger 1 Gene

Homo sapiens

Also known as NOS1; NOS-1; SPGF12; EC_Rep1a; ZC2HC12A

Gene ID: 340719 | Gene type: protein coding

About NANOS1

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,029,714-119,033,730 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 3 phenotypes.

Summary

This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

NANOS1 Products(1)

mRNA	Protein	Name
NM_199461.4	NP_955631.1	nanos homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme activator activity	IDA IDA: Inferred from direct assay	24736845	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17047063	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IDA IDA: Inferred from direct assay	18223680	GOA
involved in epithelial cell migration	IDA IDA: Inferred from direct assay	17047063	GOA
involved in mRNA destabilization	IDA IDA: Inferred from direct assay	24736845	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	24736845	GOA
acts upstream of or within post-transcriptional regulation of gene expression	IDA IDA: Inferred from direct assay	25100735	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12690449	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17047063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NANOS1 Protein Structure

zf-nanos

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

nanos homolog 1

Related Diseases

Diseases

Alias

Spermatogenic Failure 12

SPGF12

Male Infertility With Teratozoospermia Due To Single Gene Mutation

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation

Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Testis Seminoma

Seminoma Of Testis	Seminoma Testis
Testicular Seminoma Pure	Seminoma

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome	Deafness-Hermann Type Symphalangism Syndrome
Facio-Audio-Symphalangism	Hearing Loss-Hermann Type Symphalangism Syndrome
Wl Syndrome	Multiple Synostosis Syndrome

Cerebrooculofacioskeletal Syndrome 2

COFS2	Cerebro-Oculo-Facio-Skeletal Syndrome 2
Cofs Syndrome

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09021	NANOS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NANOS1	MGD	MGI:2669254
Rattus norvegicus	NANOS1	RGD	RGD:1308194
Bos taurus	NANOS1	VGNC	VGNC:106833
Macaca mulatta	NANOS1	VGNC	VGNC:106078

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