NANOS3 - nanos C2HC-type zinc finger 3 Gene

Homo sapiens

Also known as NOS3; NANOS1L; ZC2HC12C

Gene ID: 342977 | Gene type: protein coding

About NANOS3

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:13,862,036-13,880,757 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 205 orthologues and 2 paralogues. Biased expression in testis (RPKM 1.4), brain (RPKM 1.0) and 7 other tissues.

Summary

Predicted to enable mRNA binding activity. Involved in germ cell development; negative regulation of translation; and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NANOS3 Products(1)

mRNA	Protein	Name
NM_001098622.3	NP_001092092.1	nanos homolog 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme activator activity	IDA IDA: Inferred from direct assay	24736845	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24736845	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in germ cell development	IMP IMP: Inferred from mutant phenotype	21421998	GOA
involved in mRNA destabilization	IDA IDA: Inferred from direct assay	24736845	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	24736845	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21421998	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21421998	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22899867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NANOS3 Protein Structure

zf-nanos

0
100
173 a.a.

Protein Preferred Names

Protein Names

nanos homolog 3

Related Diseases

Diseases

Alias

Freemartinism

Brain Germinoma

Intracranial Germinoma

Germinoma Of The Brain

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Spermatocytoma

Spermatocytic Seminoma

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09023	NANOS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NANOS3	VGNC	VGNC:63720
Mus musculus	NANOS3	MGD	MGI:2675387
Macaca mulatta	NANOS3	VGNC	VGNC:75004
Rattus norvegicus	NANOS3	RGD	RGD:1306672
Canis familiaris	NANOS3	VGNC	VGNC:81895

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