CAVIN4 - caveolae associated protein 4 Gene

Homo sapiens

Also known as MURC; cavin-4

Gene ID: 347273 | Gene type: protein coding

About CAVIN4

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:100,576,867-100,588,389 (from NCBI)

This gene has 1 transcript (splice variant), 273 orthologues and 3 paralogues. Biased expression in heart (RPKM 18.1), prostate (RPKM 5.6) and 2 other tissues.

Summary

This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]

CAVIN4 Products(1)

mRNA	Protein	Name
NM_001018116.2	NP_001018126.1	caveolae-associated protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24567387	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21642240	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	19525939	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26497963	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAVIN4 Protein Structure

PTRF_SDPR

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

caveolae-associated protein 4

muscle related coiled-coil protein

CAVIN4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAVIN4	Q5BKX8	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	32296183
Intra	CAVIN4	Q5BKX8	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lipodystrophy, Congenital Generalized, Type 4

Congenital Generalized Lipodystrophy Type 4	CGL4
Berardinelli-Seip Congenital Lipodystrophy, Type 4, With Muscular Dystrophy	Lipodystrophy, Berardinelli-Seip Congenital, Type 4, With Muscular Dystrophy
Berardinelli-Seip Congenital Lipodystrophy Type 4 With Muscular Dystrophy	Generalized Congenital Lipodystrophy With Myopathy
Congenital Generalised Lipodystrophy Type 4	Generalised Congenital Lipodystrophy Type 4
Generalised Congenital Lipodystrophy With Myopathy	Generalized Congenital Lipodystrophy Type 4
Gcl4	Congenital Generalized Lipodystrophy 4
Berardinelli-Seip Congenital Lipodystrophy Type 4

Myopathy, Congenital, Bailey-Bloch

Native American Myopathy	Nam
MYPBB	Myopathy, Congenital, Baily-Bloch
Anti-Hmg-Coa Myopathy	Anti-Srp Myopathy
Autoimmune Necrotizing Myositis	Imnm
Immune Myopathy With Myocyte Necrosis	Immune-Mediated Necrotizing Myopathy
Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia	Necrotizing Autoimmune Myopathy
Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome	Congenital Myopathy With Cleft Palate And Malignant Hyperthermia

Alzheimer Disease 8

Ad8	Alzheimer'S Disease 8
Alzheimer Disease, Familial, 8	Alzheimer Disease, Familial 8
Alzheimer'S Disease 8, Late Onset

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01991	CAVIN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CAVIN4	RGD	RGD:1310395
Mus musculus	CAVIN4	MGD	MGI:1915266
Canis familiaris	CAVIN4	VGNC	VGNC:38756
Felis catus	CAVIN4	VGNC	VGNC:102905
Bos taurus	CAVIN4	VGNC	VGNC:26805

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