NUP43 - nucleoporin 43 Gene

Homo sapiens

Also known as p42; bA350J20.1

Gene ID: 348995 | Gene type: protein coding

About NUP43

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,724,315-149,749,358 (from NCBI)

This gene has 6 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in lymph node (RPKM 6.0), appendix (RPKM 5.2) and 25 other tissues.

Summary

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]

NUP43 Products(1)

mRNA	Protein	Name
NM_198887.3	NP_942590.1	nucleoporin Nup43

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15146057	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	15146057	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	24315095	GOA
part of nuclear pore outer ring	IDA IDA: Inferred from direct assay	17360435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP43 Protein Structure

WD40

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

nucleoporin Nup43

nucleoporin 43kDa

NUP43 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUP43	Q8NFH3	PARK7	Homo sapiens	Q99497	Validated Y2H	32814053
Intra	NUP43	Q8NFH3	PARK7	Homo sapiens	Q99497	Y2H Pooling	32814053
Intra	NUP43	Q8NFH3	PARK7	Homo sapiens	Q99497	Y2H Array	32814053
Intra	NUP43	Q8NFH3	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	NUP43	Q8NFH3	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	NUP43	Q8NFH3	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	NUP43	Q8NFH3	PRPF40A	Homo sapiens	O75400-2	Y2H Pooling	32814053
Intra	NUP43	Q8NFH3	PRPF40A	Homo sapiens	O75400-2	Validated Y2H	32814053
Intra	NUP43	Q8NFH3	PRPF40A	Homo sapiens	O75400-2	Y2H Array	32814053
Intra	NUP43	Q8NFH3	CCK	Homo sapiens	P06307	Validated Y2H	32814053
Intra	NUP43	Q8NFH3	CCK	Homo sapiens	P06307	Y2H Array	32814053
Intra	NUP43	Q8NFH3	CCK	Homo sapiens	P06307	Y2H Pooling	32814053
Intra	NUP43	Q8NFH3	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	NUP43	Q8NFH3	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	NUP43	Q8NFH3	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	NUP43	Q8NFH3	HEXB	Homo sapiens	P07686	Y2H Array	32814053
Intra	NUP43	Q8NFH3	HEXB	Homo sapiens	P07686	Validated Y2H	32814053
Intra	NUP43	Q8NFH3	HEXB	Homo sapiens	P07686	Y2H Pooling	32814053
Intra	NUP43	Q8NFH3	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	NUP43	Q8NFH3	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	NUP43	Q8NFH3	CASP6	Homo sapiens	P55212	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09694	NUP43 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NUP43	VGNC	VGNC:44055
Bos taurus	NUP43	VGNC	VGNC:32361
Rattus norvegicus	NUP43	RGD	RGD:1596513
Mus musculus	NUP43	MGD	MGI:1917162
Macaca mulatta	NUP43	VGNC	VGNC:83438
Felis catus	NUP43	VGNC	VGNC:63926

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