IGHG2 - immunoglobulin heavy constant gamma 2 (G2m marker) Gene

Homo sapiens

Gene ID: 3501 | Gene type: other

About IGHG2

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,643,203-105,644,789 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 121 orthologues, 82 paralogues and is associated with 1 phenotype.

Summary

Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to Other organism; and phagocytosis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16457820	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	25645918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGHG2 Protein Structure

C1-set

0
100
200
300
326 a.a.

IGHG2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	IGHG2	P01859	q28109_bovin	Bos taurus	Q28109	Biochemical	16457820
Cross	IGHG2	P01859	q28109_bovin	Bos taurus	Q28109	Competition Binding	16457820

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IGHG2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72605	IgG2 Fc Protein, Human (V161M, S257A, HEK293)	P01859-1 (E99-K326, V161M, S257A)	≥95%

Related Diseases

Diseases

Alias

Immunoglobulin Kappa Light Chain Deficiency

Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency	IGKCD
Kappa Chain Deficiency	Kappa Light Chain Deficiency
Kappa-Chain Deficiency	Igg Subclass Deficiency With Iga Subclass Deficiency
Isolated Igg Subclass Deficiency	Selective Igg Subclass Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IGHG2	NCBI

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