JCHAIN - joining chain of multimeric IgA and IgM Gene

Homo sapiens

Also known as IGJ; JCH; IGCJ

Gene ID: 3512 | Gene type: protein coding

About JCHAIN

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,655,541-70,666,508 (from NCBI)

This gene has 5 transcripts (splice variants) and 126 orthologues. Biased expression in colon (RPKM 2264.9), duodenum (RPKM 2014.1) and 10 other tissues.

Summary

Enables IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including defense response to other organism; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]

JCHAIN Products(1)

mRNA	Protein	Name
NM_144646.4	NP_653247.1	immunoglobulin J chain precursor

JCHAIN Protein Structure

Ig_J_chain

0
100
159 a.a.

Protein Preferred Names

Protein Names

immunoglobulin J chain

IgJ chain

Recombinant JCHAIN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74842	IgJ Protein, Human (His)	P01591/NP_653247.1 (Q23-D159)	≥95%

Related Diseases

Diseases

Alias

Alpha Chain Disease

Seligmann'S Disease

Immunoproliferative Small Intestinal Disease

Mu Chain Disease

Mu-Chain Disease

Epiphyseal Chondrodysplasia, Miura Type

ECDM	Tall Stature-Scoliosis-Macrodactyly Of The Great Toes Syndrome
Miura Type Epiphyseal Chondrodysplasia	Tall Stature-Scoliosis-Macrodactyly Of The Halluces Syndrome
Tall Stature-Long Halluces-Multiple Extra-Epiphyses Syndrome	Chondrodysplasia, Epiphyseal, Miura Type

Immunoglobulin Alpha Deficiency

Iga Deficiency	Gamma-A-Globulin Deficiency
Immunoglobulin A Deficiency

Hodgkin'S Lymphoma, Lymphocytic-Histiocytic Predominance

Hodgkin Disease	Hodgkin Lymphoma, Lymphocyte-Rich
Hodgkin Lymphoma, Lymphocytic-Histiocytic Predominance	Hodgkin'S Disease, Lymphocyte Predominance
Lymphocyte Rich Hodgkin'S Disease	Lymphocyte Rich Classical Hodgkin Lymphoma

Heavy Chain Disease

Hcd

Ciliary Dyskinesia, Primary, 7

Primary Ciliary Dyskinesia 7	CILD7
Ciliary Dyskinesia, Primary, 7, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 7 With Or Without Situs Inversus
Ics7	Immotile Cilia Syndrome 7
Dyskinesia, Ciliary, Primary, 7

Isolated Growth Hormone Deficiency

Congenital Ighd	Congenital Isolated Gh Deficiency
Congenital Isolated Growth Hormone Deficiency	Non-Acquired Isolated Growth Hormone Deficiency
Pituitary Dwarfism	Dwarfism, Pituitary
Isolated Somatotropin Deficiency	Isolated Congenital Growth Hormone Deficiency
Familial Isolated Growth Hormone Deficiency	Ighd
Dwarfism, Growth Hormone Deficiency	Growth Hormone Deficiency Dwarfism
Isolated Gh Deficiency	Isolated Hgh Deficiency
Isolated Human Growth Hormone Deficiency	Isolated Somatotropin Deficiency Disorder
Dwarfism Pituitary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3479	Insulin (swine)		98.36%	Unkown
HY-P4890A	Relaxin H3 (human) (TFA)		/	Unkown
HY-P10204	FZD7 antagonist 1		/	Unkown
HY-P1372	PKC ζ pseudosubstrate	Inhibitor	/	Unkown
HY-P4062	Insulin peglispro		/	Unkown
HY-P4890	Relaxin H3 (human)		/	Unkown
HY-RS07033	JCHAIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JCHAIN	VGNC	VGNC:106622
Canis familiaris	JCHAIN	VGNC	VGNC:42184
Rattus norvegicus	JCHAIN	RGD	RGD:1310155
Felis catus	JCHAIN	VGNC	VGNC:107339
Bos taurus	JCHAIN	VGNC	VGNC:30373
Mus musculus	JCHAIN	MGD	MGI:96493
Others	JCHAIN	NCBI

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