Hcar2 - hydroxycarboxylic acid receptor 2 Gene

Rattus norvegicus

Also known as Hm74; Hm74b; Pumag; Niacr1; rHM74b; Gpr109a; Gpr109b

Gene ID: 353250 | Gene type: protein coding

About Hcar2

Primary_assembly 12: 32,726,184-32,728,504 forward strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 164 orthologues, 13 paralogues and is associated with 5 phenotypes.

Summary

Enables nicotinic acid receptor activity. Involved in negative regulation of lipid catabolic process and positive regulation of Adiponectin secretion. Predicted to be located in cell junction and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human HCAR2 (hydroxycarboxylic acid receptor 2) and HCAR3 (hydroxycarboxylic acid receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Hcar2 Products(1)

mRNA	Protein	Name
NM_181476.2	NP_852141.1	hydroxycarboxylic acid receptor 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables nicotinic acid receptor activity	IDA IDA: Inferred from direct assay	19141678	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	19141678	RGD
involved in positive regulation of adiponectin secretion	IDA IDA: Inferred from direct assay	19141678	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hcar2 Protein Structure

7tmA_HCAR1-3

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

hydroxycarboxylic acid receptor 2

G protein-coupled receptor 109B	G protein-coupled receptor Hm74b
G-protein coupled receptor 109	G-protein coupled receptor 109A
G-protein coupled receptor HM74	interferon-gamma inducible gene, Puma-g
niacin receptor 1	nicotinic acid receptor
protein PUMA-G

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06038	HCAR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-156025	HCAR2 agonist 1		/	Unkown
HY-RS06039	Hcar2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06040	Hcar2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hcar2	NCBI	NCBI:338442

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