IL12A - interleukin 12A Gene

Homo sapiens

Also known as P35; CLMF; NFSK; NKSF1; IL-12A

Gene ID: 3592 | Gene type: protein coding

About IL12A

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:159,988,835-159,996,019 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and is associated with 2 phenotypes. Broad expression in esophagus (RPKM 2.2), lung (RPKM 1.4) and 19 other tissues.

Summary

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

IL12A Products(4)

mRNA	Protein	Name
NM_001354582.2	NP_001341511.1	interleukin-12 subunit alpha isoform 2
NM_001397992.1	NP_001384921.1	interleukin-12 subunit alpha isoform 4 precursor
NM_001354583.2	NP_001341512.1	interleukin-12 subunit alpha isoform 3
NM_000882.4	NP_000873.2	interleukin-12 subunit alpha isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to cytokine activity	IDA IDA: Inferred from direct assay	1674604	GOA
enables cytokine activity	IDA IDA: Inferred from direct assay	7584494	GOA
contributes to growth factor activity	IDA IDA: Inferred from direct assay	1674604	GOA
enables interleukin-12 beta subunit binding	IPI IPI: Inferred from physical interaction	11023671	GOA
enables interleukin-27 binding	IPI IPI: Inferred from physical interaction	9342359	GOA
enables protein binding	IDA IDA: Inferred from direct assay	10899108	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7527811	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	1674604	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IDA IDA: Inferred from direct assay	7903063	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in defense response to Gram-positive bacterium	IEP IEP: Inferred from expression pattern	1357073	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	16942485	GOA
involved in interleukin-12-mediated signaling pathway	IDA IDA: Inferred from direct assay	7584494	GOA
acts upstream of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	30106099	GOA
involved in negative regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	16482511	GOA
acts upstream of or within negative regulation of protein secretion	IGI IGI: Inferred from genetic interaction	30106099	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	16942485	GOA
acts upstream of negative regulation of vascular endothelial growth factor signaling pathway	IGI IGI: Inferred from genetic interaction	30106099	GOA
involved in positive regulation of NK T cell activation	IDA IDA: Inferred from direct assay	19088061	GOA
involved in positive regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	1674604	GOA
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	7903063	GOA
involved in positive regulation of dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of lymphocyte proliferation	IDA IDA: Inferred from direct assay	1674604	GOA
involved in positive regulation of mononuclear cell proliferation	IMP IMP: Inferred from mutant phenotype	11023671	GOA
involved in positive regulation of natural killer cell activation	IDA IDA: Inferred from direct assay	1674604	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	2204066	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA IDA: Inferred from direct assay	7903063	GOA
involved in positive regulation of smooth muscle cell apoptotic process	IDA IDA: Inferred from direct assay	16942485	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	1674604	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	12372421	GOA
involved in response to UV-B	IDA IDA: Inferred from direct assay	8992506	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	7605994	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	16548883	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	10899108	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	16456693	GOA
part of interleukin-12 complex	IDA IDA: Inferred from direct assay	2204066	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL12A Protein Structure

IL12

0
100
200
253 a.a.

Protein Preferred Names

Protein Names

interleukin-12 subunit alpha

CLMF p35	IL-12, subunit p35
IL35 subunit	NF cell stimulatory factor chain 1
NK cell stimulatory factor chain 1	cytotoxic lymphocyte maturation factor 1, p35
cytotoxic lymphocyte maturation factor 35 kDa subunit	interleukin 12, p35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	interleukin-12 alpha chain

IL12A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL12A	P29459	IL12B	Homo sapiens	P29460	Comig Non-Denat Gel	7527811

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL12A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7032	IL-12 Protein, Human (HEK293)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P70338	IL-35 Protein, Human (HEK293, Fc)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P7032G	GMP IL-12 Protein, Human (HEK293)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P73156	GMP IL-12 Protein, Human (HEK293, His)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P73880	IL-35 Protein, Human (HEK293, Flag-His)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P73882	IL-35 Protein, Human (HEK293, His, hFc-Flag)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P73898	IL-12 Protein, Human (HEK293, His)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P77511	IL-12 Protein, Human (Biotinylated, HEK293, His)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P77702	IL-12 Protein, Human (Biotinylated, HEK293, His-Avi)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P700099AF	Animal-Free IL-12 alpha Protein, Human (His)	P29459 (R23-S219)	≥95%

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Properdin Deficiency, X-Linked

Properdin Deficiency	PFD
CFPD	Properdin P Factor Deficiency
Complement Factor Properdin Deficiency	X-Linked Properdin Deficiency
Properdin Deficiency, Type I	Properdin Deficiency, Type 1
Properdin Deficiency Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06677	IL12A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06678	Il12a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06679	Il12a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL12A	RGD	RGD:620562
Mus musculus	IL12A	MGD	MGI:96539
Canis familiaris	IL12A	VGNC	VGNC:41932
Bos taurus	IL12A	VGNC	VGNC:30110
Felis catus	IL12A	VGNC	VGNC:102761
Macaca mulatta	IL12A	VGNC	VGNC:84168
Macaca fascicularis	IL12A	NCBI	NCBI:102115316
Others	IL12A	NCBI

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