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Interleukin-12 (IL-12) is a receptor for IL-12R and belongs to the type I cytokine receptor family, subfamily 4. This cytokine acts as a growth factor for activated T and NK cells, enhances the lysate activity of natural killer cells or lymphokine-activated killer cells, and stimulates IFN-γ production through resting PBMC. Il-12β (IL-12B) is the main functional chain of IL-12. It can heterodimerize with IL-12 p35 subunit (IL-12A) to form IL-12, or with IL-23 p19 subunit (IL23A) to form IL-23[1]. IL-12 and IL23 belong to the IL-12 family, participate in proinflammatory response, and are expressed by activated macrophages, and play different regulatory functions as necessary inducers of Th1 cell development[2]. More importantly, IL-23 is a heterodimer factor that plays a role in innate and adaptive immunity and may, together with IL-17, constitute the acute response of peripheral tissue to infection. In terms of signal transduction, IL-12 signaling is mediated by p-STAT4, while IL-23 signaling is regulated by IL-23 binding by p-STAT1 and p-STAT3[3]. Moreover, the heterodimer receptor complex composed of IL12RB1 and IL23R further activates the Jak-STAT signaling cascade, stimulates memory rather than naive T cells, and promotes the production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation, so it may lead to autoimmune inflammatory diseases[4].
Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Human (HEK293, His), a recombinant GMP-grade protein, is produced in HEK293 cells with a C-Terminal His-tag . It consists of IL-12A (M1-S219) and IL-12B (M1-S328).
IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (M1-S328) is produced in HEK293 cells with a C-Terminal Fc-tag.
Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Human (547a.a, HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag . It consists of IL-12A (M1-S219) and IL-12B (M1-S328).
IL-35 protein plays a key role in immune regulation, forming IL-12 cytokine with IL12B or IL-35 cytokine with EBI3/IL27B. IL-12 modulates T cell and natural killer cell responses and induces interferon gamma production. Animal-Free IL-12 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived animal-FreeIL-12 protein, expressed by HEK293 , with C-His labeled tag. Animal-Free IL-12 Protein, Human (HEK293, His), has molecular weight of ~59.55 kDa.
Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. GMP IL-12 Protein, Human (HEK293), a recombinant GMP-grade protein, is produced in HEK293 cells. It consists of IL-12A and IL-12B.
IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (I23-S328) is produced in HEK293 cells with tag free.
IL-12 protein is a immune-suppressive heterodimeric cytokine, composed by IL-12A subunit (IL-12p35) and IL-12B subunit (IL-12p40), is naturally produced by dendritic cells. IL-12 exerts functions to activate and link the innate and acquired immune responses. IL-12 Protein, Mouse is produced in HEK293 cells, with total length of 506 amino acids and tag free.
IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-S335) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Mouse (M23-S335) is produced in HEK293 cells with a C-Terminal His-tag.
Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of IL-12A (M1-A215) and IL-12B (M1-S335).
IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-S335) with a lg-like domain (43-90 a.a). IL-12 beta Protein, Rat (M1-S335) is produced in HEK293 cells with a C-Terminal His-tag.
IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-N328) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Marmoset is produced in HEK293 cells with a C-Terminal hFc-tag.
IL-35 protein plays a key role in immune regulation, forming IL-12 cytokine with IL12B or IL-35 cytokine with EBI3/IL27B. IL-12 modulates T cell and natural killer cell responses and induces interferon gamma production. IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived IL-12 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. IL-12 Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of ~40-45 kDa.
IL-35 protein plays a key role in immune regulation, forming IL-12 cytokine with IL12B or IL-35 cytokine with EBI3/IL27B. IL-12 modulates T cell and natural killer cell responses and induces interferon gamma production. Animal-Free IL-12 alpha Protein, Human (His) is the recombinant human-derived animal-FreeIL-12 alpha protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-12 alpha Protein, Human (His) is 197 a.a., with molecular weight of ~23.48 kDa.
IL-12 beta protein is a multifunctional cytokine that serves as a growth factor for activated T cells and NK cells, amplifies the lytic activity of NK/lymphokine-activated killer cells, and induces IFN production by resting peripheral blood mononuclear cells -γ. peripheral blood mononuclear cells). Animal-Free IL-12 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-12 beta protein, expressed by E. coli , with His labeled tag. The total length of Animal-Free IL-12 beta Protein, Human (His) is 306 a.a., with molecular weight of ~35.64 kDa.
IL-12 alpha protein forms two cytokines: IL-12 and IL-35. It modulates T cell and natural killer cell responses, induces IFN-γ production, and promotes Th1 cell differentiation. Animal-Free IL-12 alpha Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-12 alpha protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-12 alpha Protein, Mouse (His) is 193 a.a., with molecular weight of ~22.65 kDa.
IL-12 beta protein is a cytokine that acts as a growth factor for activated T cells and NK cells, enhances lytic activity and stimulates IFN-γ production. It combines with IL23A to form IL-23, a cytokine critical in innate and adaptive immunity. Animal-Free IL-12 beta Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-12 beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-12 beta Protein, Mouse (His) is 313 a.a., with molecular weight of ~36.60 kDa.
IL-12 Protein, forming a heterodimer with IL23A, generates the cytokine IL-23, pivotal in innate and adaptive immunity. Collaborating with IL-17, IL-23 prompts an acute response to infection in peripheral tissues. Binding to the receptor complex IL12RB1 and IL23R, IL-23 activates Jak-Stat signaling, preferentially stimulates memory T-cells, and induces pro-inflammatory cytokine production. Implicated in autoimmune inflammation and tumorigenesis, IL-23 acts as a growth factor for activated T and NK cells, enhances NK cell lytic activity, and stimulates IFN-gamma production by resting PBMC. IL-12 Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived IL-12 protein, expressed by HEK293, with C-His labeled tag. IL-12 Protein, Cynomolgus (HEK293, His), has molecular weight of 45-48 kDa (IL-12B) & 38-44 kDa (IL-12A), respectively.
