Top2a - DNA topoisomerase II alpha Gene

Rattus norvegicus

Gene ID: 360243 | Gene type: protein coding

About Top2a

Primary_assembly 10: 83,945,735-83,976,874 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 25 phenotypes. Biased expression in Thymus (RPKM 915.5), Spleen (RPKM 349.2) and 6 other tissues.

Summary

Enables several functions, including ATP binding activity; DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and chromatin binding activity. Involved in several processes, including DNA topological change; cerebellar cortex formation; and response to parathyroid hormone. Located in nucleolus. Part of DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Orthologous to human TOP2A (DNA Topoisomerase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Top2a Products(1)

mRNA	Protein	Name
NM_001393768.1	NP_001380697.1	DNA topoisomerase 2-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11334111	RGD
enables DNA binding	IDA IDA: Inferred from direct assay	11334111	RGD
enables DNA topoisomerase activity	IDA IDA: Inferred from direct assay	11334111	RGD
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA IDA: Inferred from direct assay	11334111	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	11334111	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11334111	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA topological change	IDA IDA: Inferred from direct assay	11334111	RGD
involved in cerebellar Purkinje cell differentiation	IEP IEP: Inferred from expression pattern	11170002	RGD
involved in cerebellar granule cell differentiation	IEP IEP: Inferred from expression pattern	11170002	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	22965249	RGD
involved in response to parathyroid hormone	IEP IEP: Inferred from expression pattern	10709994	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	14766721	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	IDA IDA: Inferred from direct assay	11334111	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Top2a Protein Structure

PTZ00108

DTHCT

0
300
600
900
1200
1528 a.a.

Protein Preferred Names

Protein Names

DNA topoisomerase 2-alpha

DNA topoisomerase II, alpha isozyme	topoisomerase (DNA) 2 alpha
topoisomerase (DNA) II alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111630	PluriSIn #2	Inhibitor	≥98.0%	Unkown
HY-RS14894	TOP2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164143	T638	Inhibitor	/	Unkown
HY-RS14895	Top2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14896	Top2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Top2a	NCBI	NCBI:7153

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