IMPA2 - inositol monophosphatase 2 Gene

Homo sapiens

Gene ID: 3613 | Gene type: protein coding

About IMPA2

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:11,981,507-12,030,877 (from NCBI)

This gene has 12 transcripts (splice variants), 158 orthologues and 4 paralogues. Broad expression in kidney (RPKM 73.3), skin (RPKM 38.8) and 18 other tissues.

Summary

This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

IMPA2 Products(1)

mRNA	Protein	Name
NM_014214.3	NP_055029.1	inositol monophosphatase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol monophosphate 1-phosphatase activity	IDA IDA: Inferred from direct assay	17068342	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17068342	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to lithium ion	IDA IDA: Inferred from direct assay	15504365	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17068342	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMPA2 Protein Structure

Inositol_P

0
100
200
288 a.a.

Protein Preferred Names

Protein Names

inositol monophosphatase 2

IMP 2

IMPA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IMPA2	O14732	SLC44A3	Homo sapiens	Q8N4M1-3	Validated Y2H	32296183
Intra	IMPA2	O14732	IMPA1	Homo sapiens	P29218-3	Y2H Prey Pooling	32296183
Intra	IMPA2	O14732	IMPA1	Homo sapiens	P29218-3	Validated Y2H	32296183
Intra	IMPA2	O14732	IMPA1	Homo sapiens	P29218-3	Y2H Array	32296183
Intra	IMPA2	O14732	UBA3	Homo sapiens	Q8TBC4	Y2H Prey Pooling	32296183
Intra	IMPA2	O14732	UBA3	Homo sapiens	Q8TBC4	Validated Y2H	25416956
Intra	IMPA2	O14732	UBA3	Homo sapiens	Q8TBC4	Validated Y2H	32296183
Intra	IMPA2	O14732	UBA3	Homo sapiens	Q8TBC4	Y2H Array	32296183
Intra	IMPA2	O14732	IMPA1	Homo sapiens	P29218	Y2H Prey Pooling	25416956
Intra	IMPA2	O14732	IMPA1	Homo sapiens	P29218	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IMPA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70197	IMPA2 Protein, Human (His)	O14732-1 (M1-K288)	≥95%

Related Diseases

Diseases

Alias

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Febrile Seizures

Febrile Seizure	Febrile Convulsions
Seizures Febrile

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Ring Dermoid Of Cornea

RDC	Ring Dermoid Syndrome
Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension	Dermoid Of Cornea, Ring

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Familial Febrile Seizures

Familial Febrile Convulsions	Feb
Febrile Seizures, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06796	IMPA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IMPA2	RGD	RGD:628692
Canis familiaris	IMPA2	VGNC	VGNC:49913
Mus musculus	IMPA2	MGD	MGI:2149728
Bos taurus	IMPA2	VGNC	VGNC:30185
Others	IMPA2	NCBI

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