2. Gene
  3. UBA3 - ubiquitin like modifier activating enzyme 3 Gene

UBA3 - ubiquitin like modifier activating enzyme 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NAE2; UBE1C; hUBA3

Gene ID: 9039 | Gene type: protein coding

About UBA3

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:69,054,730-69,080,373 (from NCBI)

This gene has 13 transcripts (splice variants), 270 orthologues and 9 paralogues. Ubiquitous expression in heart (RPKM 24.5), lymph node (RPKM 24.0) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating Enzyme family. The encoded Enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the Enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UBA3 Products(3)

mRNA Protein Name
NM_001363861.1 NP_001350790.1 NEDD8-activating enzyme E1 catalytic subunit isoform 3
NM_003968.4 NP_003959.3 NEDD8-activating enzyme E1 catalytic subunit isoform 1
NM_198195.2 NP_937838.1 NEDD8-activating enzyme E1 catalytic subunit isoform 2

UBA3 Protein Structure

ThiF

ThiF: ThiF family (69 - 211)

UBA_e1_thiolCys

UBA_e1_thiolCys: Ubiquitin-activating enzyme active site (217 - 260)

(270 - 334)

E2_bind

E2_bind: E2 binding domain (374 - 462)

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  • 463 a.a.
Protein Preferred Names Protein Names

NEDD8-activating enzyme E1 catalytic subunit

NEDD8-activating enzyme E1 subunit 2

UBA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBA3 Q8TBC4 APOE Homo sapiens P02649
Y2H Array
32814053
Intra
UBA3 Q8TBC4 APOE Homo sapiens P02649
Y2H Pooling
32814053
Intra
UBA3 Q8TBC4 APOE Homo sapiens P02649
Validated Y2H
32814053
Intra
UBA3 Q8TBC4 CPNE2 Homo sapiens Q96FN4
Validated Y2H
25416956
Intra
UBA3 Q8TBC4 CPNE2 Homo sapiens Q96FN4
Validated Y2H
32296183
Intra
UBA3 Q8TBC4 CPNE2 Homo sapiens Q96FN4
Y2H Array
25416956
Intra
UBA3 Q8TBC4 UBA3 Homo sapiens Q8TBC4
Y2H Prey Pooling
32296183
Intra
UBA3 Q8TBC4 IMPA2 Homo sapiens O14732
Y2H Array
25416956
Intra
UBA3 Q8TBC4 UBA3 Homo sapiens Q8TBC4
Validated Y2H
32296183
Intra
UBA3 Q8TBC4 UBA3 Homo sapiens Q8TBC4
Y2H Array
25416956
Intra
UBA3 Q8TBC4 IMPA2 Homo sapiens O14732
Y2H Prey Pooling
25416956
Intra
UBA3 Q8TBC4 UBA3 Homo sapiens Q8TBC4
Y2H Array
32296183
Intra
UBA3 Q8TBC4 NAE1 Homo sapiens Q13564
Y2H Prey Pooling
32296183
Intra
UBA3 Q8TBC4 NAE1 Homo sapiens Q13564
Y2H Array
32296183
Intra
UBA3 Q8TBC4 DUSP23 Homo sapiens Q9BVJ7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

UBA3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83551 NEDD8 Activating Enzyme E1C Antibody (YA3296) WB Human, Mouse

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15321 UBA3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBA3 VGNC VGNC:78689
Rattus norvegicus UBA3 RGD RGD:621084
Felis catus UBA3 VGNC VGNC:66748
Bos taurus UBA3 VGNC VGNC:36563
Canis familiaris UBA3 VGNC VGNC:48038
Mus musculus UBA3 MGD MGI:1341217
Others UBA3 NCBI