2. Gene
  3. Pik3c2a - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Gene

Pik3c2a - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 361632 | Gene type: protein coding

About Pik3c2a

Primary_assembly 1: 170,577,942-170,683,472 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 222 orthologues, 9 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 23.7), Lung (RPKM 188.6) and 9 other tissues.

Summary

Predicted to enable clathrin binding activity and phosphatidylinositol 3-kinase activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase signaling; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to act upstream of or within autophagosome organization; cellular response to starvation; and negative regulation of zinc ion transmembrane transport. Predicted to be located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c2a Products(1)

mRNA Protein Name
NM_001108500.1 NP_001101970.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Pik3c2a Protein Structure

PI3K_rbd

PI3K_rbd: pfam00794 (420 - 513)

C2A_PI3K_class_II

C2A_PI3K_class_II: cd04012 (677 - 849)

PI3Ka_II

PI3Ka_II: cd00869 (870 - 1038)

PI3Kc_C2_alpha

PI3Kc_C2_alpha: cd05176 (1043 - 1395)

PX_PI3K_C2_alpha

PX_PI3K_C2_alpha: cd07289 (1426 - 1534)

C2B_PI3K_class_II

C2B_PI3K_class_II: cd08381 (1560 - 1681)

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  • 1687 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide

phosphoinositide-3-kinase, class 2, alpha polypeptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112608 CHMFL-PI3KD-317 Inhibitor 98.04% Unkown
HY-RS10511 PIK3C2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10512 Pik3c2a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10513 Pik3c2a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3c2a NCBI NCBI:5286