2. Gene
  3. PNPLA2 - patatin-like phospholipase domain containing 2 Gene

PNPLA2 - patatin-like phospholipase domain containing 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1309044

Gene ID: 361676 | Gene type: protein coding

About PNPLA2

Primary_assembly 1: 196,552,723-196,557,805 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 193 orthologues, 4 paralogues and is associated with 11 phenotypes. Biased expression in Thymus (RPKM 668.7), Adrenal (RPKM 61.7) and 9 other tissues.

Summary

Predicted to enable retinyl-palmitate esterase activity and triglyceride Lipase activity. Predicted to be involved in several processes, including acylglycerol metabolic process; negative regulation of sequestering of triglyceride; and positive regulation of triglyceride catabolic process. Predicted to act upstream of or within cellular lipid catabolic process and lipid droplet organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA2 (patatin like Phospholipase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

PNPLA2 Products(1)

mRNA Protein Name
NM_001108509.2 NP_001101979.2 patatin-like phospholipase domain-containing protein 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23408028 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PNPLA2 Protein Structure

Pat_PNPLA2

Pat_PNPLA2: cd07220 (3 - 251)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
Protein Preferred Names Protein Names

patatin-like phospholipase domain-containing protein 2

adipose triglyceride lipase

calcium-independent phospholipase A2-zeta

iPLA2-zeta

patatin-like phospholipase domain-containing protein 2-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10791 PNPLA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10792 Pnpla2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10793 PNPLA2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PNPLA2 NCBI NCBI:57104