Agl - amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase Gene

Rattus norvegicus

Gene ID: 362029 | Gene type: protein coding

About Agl

Summary

Enables 4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity; and carbohydrate binding activity. Involved in glycogen catabolic process; response to glucocorticoid; and response to nutrient. Located in sarcoplasmic reticulum. Used to study uremia. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Apr 2022]

Agl Products(1)

mRNA	Protein	Name
NM_001108564.1	NP_001102034.1	glycogen debranching enzyme

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 4-alpha-glucanotransferase activity	IDA IDA: Inferred from direct assay	6449198	RGD
enables amylo-alpha-1,6-glucosidase activity	IDA IDA: Inferred from direct assay	6449198	RGD
enables carbohydrate binding	IDA IDA: Inferred from direct assay	6449198	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycogen catabolic process	IDA IDA: Inferred from direct assay	6449198	RGD
involved in glycogen catabolic process	IMP IMP: Inferred from mutant phenotype	9281456	RGD
involved in response to glucocorticoid	IDA IDA: Inferred from direct assay	120213	RGD
involved in response to hormone	IDA IDA: Inferred from direct assay	1413626	RGD
involved in response to nutrient	IDA IDA: Inferred from direct assay	1413626	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	15180797	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glycogen debranching enzyme

amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III)

amylo-1,6-glucosidase, 4-alpha-glucanotransferase

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13805	PP2	Inhibitor	98.34%	Unkown
HY-13804	PP1		99.00%	Unkown
HY-112720	AGL-2263	Inhibitor	98.31%	Unkown
HY-144584	AGL-0182-30		/	Unkown
HY-RS00449	AGL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-112350	AGL 2043	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agl	NCBI	NCBI:178
Macaca fascicularis	Agl	NCBI	NCBI:102141897
Mus musculus	Agl	NCBI	NCBI:77559

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