2. Gene
  3. Cenpe - centromere protein E Gene

Cenpe - centromere protein E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 362044 | Gene type: protein coding

About Cenpe

Primary_assembly 2: 223,636,998-223,695,669 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 147 orthologues, 44 paralogues and is associated with 4 phenotypes. Biased expression in Thymus (RPKM 15.), Spleen (RPKM 69.3) and 9 other tissues.

Summary

Predicted to enable several functions, including kinetochore binding activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in several processes, including kinetochore assembly; mitotic sister chromatid segregation; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Predicted to be located in several cellular components, including kinetochore; midbody; and spindle. Predicted to be part of outer kinetochore. Predicted to be active in microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Apr 2022]

Cenpe Products(5)

mRNA Protein Name
XM_006233351.3 XP_006233413.3 centromere-associated protein E isoform X3
XM_039103858.1 XP_038959786.1 centromere-associated protein E isoform X2
XM_039103859.1 XP_038959787.1 centromere-associated protein E isoform X4
XM_039103860.1 XP_038959788.1 centromere-associated protein E isoform X5
XM_006233350.3 XP_006233412.3 centromere-associated protein E isoform X1

Cenpe Protein Structure

KISc_CENP_E

KISc_CENP_E: cd01374 (5 - 328)

Smc

Smc: cl34174 (333 - 1056)

Smc

Smc: cl34174 (786 - 1602)

Smc

Smc: cl34174 (1319 - 2166)

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  • 2456 a.a.
Protein Preferred Names Protein Names

centromere-associated protein E

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10299 GSK-923295 99.82% Phase 1
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19530 PF-2771 Inhibitor 99.66% Unkown
HY-121569 Syntelin Inhibitor / Unkown
HY-161897 CENP-E-IN-2 Inhibitor / Unkown
HY-161898 CENP-E-IN-3 Inhibitor / Unkown
HY-RS02476 CENPE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02477 Cenpe Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02478 Cenpe Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cenpe NCBI NCBI:1062