Syntelin

Cat. No.: HY-121569 Purity: 98.25%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Syntelin is a selective centromere protein E (CENP-E) inhibitor with IC₅₀ at 160 nM. Syntelin has antitumor activity.

For research use only. We do not sell to patients.

Syntelin Chemical Structure

CAS No. : 438481-33-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Syntelin is a selective centromere protein E (CENP-E) inhibitor with IC₅₀ at 160 nM. Syntelin has antitumor activity^[1]^[2].

IC₅₀ & Target

CENP-E

160 nM (IC₅₀)

Molecular Weight

484.62

Formula

C₂₁H₂₀N₆O₂S₃

CAS No.

438481-33-5

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CSC1=NN=C(N1C2=CC=CC=C2)CSC3=NC(N)=C4C5=C(SC4=N3)CCCC5)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (103.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0635 mL	10.3174 mL	20.6347 mL
5 mM	0.4127 mL	2.0635 mL	4.1269 mL
10 mM	0.2063 mL	1.0317 mL	2.0635 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.25%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (249 KB) HNMR (260 KB) RP-HPLC (251 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Xue biao Yao, et al. Small molecule inhibitor syntelin against kinetochore motor protein cenp-e and use thereof. WO2012062044A1. 2012-05-18. [Content Brief]

[2]. Mullen M, et al. Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis. J Mol Cell Biol. 2022 Jan 21;13(11):834-837. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0635 mL	10.3174 mL	20.6347 mL	51.5868 mL
	5 mM	0.4127 mL	2.0635 mL	4.1269 mL	10.3174 mL
	10 mM	0.2063 mL	1.0317 mL	2.0635 mL	5.1587 mL
	15 mM	0.1376 mL	0.6878 mL	1.3756 mL	3.4391 mL
	20 mM	0.1032 mL	0.5159 mL	1.0317 mL	2.5793 mL
	25 mM	0.0825 mL	0.4127 mL	0.8254 mL	2.0635 mL
	30 mM	0.0688 mL	0.3439 mL	0.6878 mL	1.7196 mL
	40 mM	0.0516 mL	0.2579 mL	0.5159 mL	1.2897 mL
	50 mM	0.0413 mL	0.2063 mL	0.4127 mL	1.0317 mL
	60 mM	0.0344 mL	0.1720 mL	0.3439 mL	0.8598 mL
	80 mM	0.0258 mL	0.1290 mL	0.2579 mL	0.6448 mL
	100 mM	0.0206 mL	0.1032 mL	0.2063 mL	0.5159 mL

Syntelin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Syntelin438481-33-5KinesinCENP-EInhibitorantitumorinhibitorinhibit

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