Irak1 - interleukin-1 receptor-associated kinase 1 Gene

Rattus norvegicus

Also known as RGD1563841

Gene ID: 363520 | Gene type: protein coding

About Irak1

Primary_assembly X: 151,768,777-151,778,521 reverse strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 24 phenotypes. Biased expression in Kidney (RPKM 194.8), Adrenal (RPKM 179.6) and 9 other tissues.

Summary

Enables heat shock protein binding activity and protein kinase activity. Involved in several processes, including JNK cascade; cellular response to lipopolysaccharide; and positive regulation of smooth muscle cell proliferation. Located in membrane. Biomarker of brain ischemia and cognitive disorder. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Irak1 Products(1)

mRNA	Protein	Name
NM_001127555.1	NP_001121027.1	interleukin-1 receptor-associated kinase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IDA IDA: Inferred from direct assay	23324889	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	15793310	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in cellular response to heat	IDA IDA: Inferred from direct assay	23324889	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	15793310	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	15793310	RGD
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15890643	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15793310	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Irak1 Protein Structure

Death_IRAK1

PKc_like

0
200
400
600
711 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor-associated kinase 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-160487	KME-2780	Inhibitor	98.94%	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0039	Ginsenoside Rb1	Inhibitor	98.75%	Unkown
HY-103017A	JH-X-119-01	Inhibitor	99.03%	Unkown
HY-147141	HS-276	Inhibitor	98.59%	Unkown
HY-103017	JH-X-119-01 hydrochloride	Inhibitor	98.15%	Unkown
HY-111101	AZ1495	Inhibitor	98.07%	Unkown
HY-153188	JNJ-1013	Degrader	99.80%	Unkown
HY-134911	HS-243	Inhibitor	99.88%	Unkown
HY-153110A	Larotinib mesylate hydrate	Inhibitor	98.66%	Unkown
HY-153224	GLPG2534	Inhibitor	98.73%	Unkown
HY-153110	Larotinib	Inhibitor	99.50%	Unkown
HY-159953	IRAK1/4/pan-FLT3 Kinase-IN-1	Inhibitor	/	Unkown
HY-N0039R	Ginsenoside Rb1 (Standard)	Inhibitor	/	Unkown
HY-162641	AF-45	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irak1	NCBI	NCBI:3654

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