INSL3 - insulin like 3 Gene

Homo sapiens

Also known as RLF; RLNL; ley-I-L

Gene ID: 3640 | Gene type: protein coding

About INSL3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,816,512-17,821,519 (from NCBI)

This gene has 3 transcripts (splice variants), 69 orthologues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 240.7).

Summary

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

INSL3 Products(2)

mRNA	Protein	Name
NM_001265587.2	NP_001252516.1	insulin-like 3 isoform 1 precursor
NM_005543.4	NP_005534.2	insulin-like 3 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	20082125	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of epithelial cell migration	IDA IDA: Inferred from direct assay	23539510	GOA
involved in positive regulation of wound healing	IDA IDA: Inferred from direct assay	23539510	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INSL3 Protein Structure

Insulin

0
100
131 a.a.

Protein Preferred Names

Protein Names

insulin-like 3

insulin-like 3 (Leydig cell)

INSL3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	INSL3	P51460	C12orf57	Homo sapiens	Q99622	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INSL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70176	Insulin-like 3/INSL3 Protein, Human (HEK293, His)	AAI06722.1 (L21-Y131)	≥95%

Related Diseases

Diseases

Alias

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Testicular Disease

Testicular Dysfunction	Testicular Diseases
Disorder Of Testis	Testis Disorder
Testicular Disorders

Testicular Torsion

Spermatic Cord Torsion	Torsion Of Testis
Torsion Of Testicular Cord	Torsion Of Testicle
Torsion Of Spermatic Cord	Torsion Of Spermatic Cord Nos

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Infertility

Leydig Cell Tumor

Leydig Cell Neoplasm	Tumor, Leydig Cell
Leydig Cell Tumor, Benign

Hyperandrogenism

Hyperandrogenization Syndrome

Sertoli-Leydig Cell Tumor

Sertoli-Leydig Cell Tumors	Androblastoma Of Ovary
Arrhenoblastoma	Arrhenoblastoma Of Ovary
Sertoli-Leydig Cell Tumor Of The Ovary	Sertoli-Leydig Cell Tumor Of Intermediate Differentiation
Sertoli-Leydig Cell Tumor Of Ovary

Persistent Mullerian Duct Syndrome

Persistent Müllerian Duct Syndrome	Pmds
Persistent Oviduct Syndrome	Persistent Muellerian Duct Syndrome
Female Genital Ducts In Otherwise Normal Male	Hernia Uteri Inguinale
Persistent Mullerian Duct Syndrome, Types 1 And 2	Persistent Mullerian Derivatives

Hypospadias

Hypospadias Familial

Familial Hypospadias

Testicular Leydig Cell Tumor

Testicular Leydig Cell Neoplasm	Leydig Cell Tumor Of Testis
Interstitial Cell Neoplasm Of Testis

Testicular Sex Cord-Stromal Neoplasm

Sex Cord-Stromal Tumor Of Testis

Testicular Sex Cord-Stromal Tumor

Adrenal Rest Tumor

Adrenal Rest Neoplasm

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Inguinal Hernia

Hernia Inguinal	Hernia, Inguinal
Inguinal Hernias	Bubonocele
Indirect Inguinal Hernia	Direct Inguinal Hernia
Oblique Inguinal Hernia	Scrotal Hernia
Ih - [Inguinal Hernia]

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Leydig Cell Hypoplasia

46,Xy Disorder Of Sex Development Due To Lh Resistance Or Lhb Deficiency	46,Xy Disorder Of Sex Development Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
46,Xy Dsd Due To Lh Resistance Or Lhb Deficiency	46,Xy Dsd Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
46,Xy Disorder Of Sex Development Due To Lh Defects	Lh Resistance Due To Lh Receptor Deactivation
Leydig Cell Agenesis	Male Hypergonadotropic Hypogonadism Due To Lhcgr Defect
Male Pseudohermaphroditism Due To Lh Resistance Or Lhb Deficiency	Male Pseudohermaphroditism Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency
Lch	Hypoplasia, Leydig Cell

Pseudohermaphroditism

Indeterminate Sex And Pseudohermaphroditism

Prune Belly Syndrome

Eagle-Barrett Syndrome	Abdominal Muscle Deficiency Syndrome
PBS	Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism
Egbrs	Eagle-Barret Syndrome
Urethral Obstruction Sequence	Obrinsky Syndrome
Triad Syndrome	Obrisnksy Syndrome
Euos	Early Urethral Obstruction Sequence
Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction	Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism
Abdomen Muscle Deficiency Syndrome	Abdomen Muscular Deficiency Syndrome
Abdominal Muscular Deficiency Syndrome	Abdominal Muscle Aplasia Syndrome

Crisponi/Cold-Induced Sweating Syndrome 2

Cold-Induced Sweating Syndrome 2	CISS2
Sweating Syndrome, Cold-Induced, Type 2

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Androgen Insensitivity, Partial

Partial Androgen Insensitivity Syndrome	Reifenstein Syndrome
PAIS	Androgen Insensitivity, Partial, With Or Without Breast Cancer
Familial Incomplete Male Pseudohermaphroditism, Type 1	Androgen Insensitivity Syndrome, Partial
Androgen Resistance Syndrome, Partial	Reifenstein Syndrome, Partial
Partial Androgen Resistance Syndrome	Androgen Insensitivity Partial With Or Without Breast Cancer
Androgen Insensitivity Syndrome Partial	Insensitivity Syndrome, Androgen, Partial, With/Without Breast Cancer Syndrome

Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis	Testicular Germ Cell Tumor
Testicular Germ Cell Neoplasm	Testicular Malignant Germ Cell Tumor

Complete Androgen Insensitivity Syndrome

Cais	Complete Androgen Resistance Syndrome
Androgen Insensitivity Syndrome Complete	Androgen Insensitivity, Complete
Androgen-Insensitivity Syndrome	Testicular Feminization

Sex Cord-Gonadal Stromal Tumor

Sex Cord-Gonadal Stromal Tumour	Sex Cord Stromal Tumour
Sex Cord-Stromal Neoplasm	Specialized Gonadal Neoplasm
Specialized Gonadal Tumor	Specialized Gonadal Tumour
Sex Cord-Gonadal Stromal Tumors	Sex Cord-Stromal Tumor
Malignant Testicular Sex Cord-Stromal Tumor	Sex Cord Stromal Tumor Of Testis

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome	AIS
Testicular Feminization Syndrome	Androgen Receptor Deficiency
Dhtr Deficiency	Dihydrotestosterone Receptor Deficiency
Ar Deficiency	Testicular Feminization
Tfm	Androgen Insensitivity
Androgen-Insensitivity Syndrome	Goldberg-Maxwell Syndrome
Complete Androgen Insensitivity Syndrome	Cais
Feminisation - Testicular	Goldberg - Maxwell Syndrome
Androgen Insensitivity Syndrome, Complete	Morris Syndrome
Ary	AR
Insensitivity Syndrome, Androgen	Androgen Insensitivity Nos

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06840	INSL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	INSL3	MGD	MGI:108427
Bos taurus	INSL3	VGNC	VGNC:106785
Rattus norvegicus	INSL3	RGD	RGD:620117
Canis familiaris	INSL3	VGNC	VGNC:54272
Others	INSL3	NCBI