IPP - intracisternal A particle-promoted polypeptide Gene

Homo sapiens

Also known as KLHL27

Gene ID: 3652 | Gene type: protein coding

About IPP

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,694,324-45,750,653 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 54 paralogues. Ubiquitous expression in thyroid (RPKM 2.7), testis (RPKM 2.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

IPP Products(2)

mRNA	Protein	Name
NM_001145349.2	NP_001138821.1	actin-binding protein IPP isoform 2
NM_005897.3	NP_005888.1	actin-binding protein IPP isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPP Protein Structure

BTB

BACK

Kelch_1

0
100
200
300
400
500
584 a.a.

Protein Preferred Names

Protein Names

actin-binding protein IPP

kelch-like family member 27

Related Diseases

Diseases

Alias

Peroneal Nerve Paralysis

Peroneal Nerve Palsy

Progressive Myoclonus Epilepsy 10

Early-Onset Lafora Body Disease

Epm10

Villonodular Synovitis

Pigmented Villonodular Synovitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105037A	Forigerimod TFA	Inhibitor	98.89%	Phase 3

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110063	4-IPP	Inhibitor	99.46%	Unkown
HY-130573A	DMAPP triammonium		≥95.0%	Unkown
HY-105037	Forigerimod	Inhibitor	/	Unkown
HY-126825	NE21650		/	Unkown
HY-130573	DMAPP		/	Unkown
HY-RS06873	IPP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-126404	Casein hydrolysate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IPP	RGD	RGD:1306299
Felis catus	IPP	VGNC	VGNC:67816
Macaca mulatta	IPP	VGNC	VGNC:73754
Canis familiaris	IPP	VGNC	VGNC:42070
Bos taurus	IPP	VGNC	VGNC:30247
Mus musculus	IPP	MGD	MGI:96581
Others	IPP	NCBI

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