ITGA5 - integrin subunit alpha 5 Gene

Homo sapiens

Also known as FNRA; CD49e; VLA-5; VLA5A

Gene ID: 3678 | Gene type: protein coding

About ITGA5

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,395,261-54,419,266 (from NCBI)

This gene has 13 transcripts (splice variants), 268 orthologues and 17 paralogues. Broad expression in appendix (RPKM 85.6), urinary bladder (RPKM 54.1) and 19 other tissues.

Summary

The product of this gene belongs to the Integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate LIGHT and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This Integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung Cancer patients. Note that the Integrin alpha 5 and Integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

ITGA5 Products(1)

mRNA	Protein	Name
NM_002205.5	NP_002196.4	integrin alpha-5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	33962943	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12695522	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CD40 signaling pathway	IDA IDA: Inferred from direct assay	31331973	GOA
involved in cell adhesion	IDA IDA: Inferred from direct assay	19703720	GOA
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	12807887	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	19933311	GOA
involved in endodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	23154389	GOA
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20563599	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	31331973	GOA
involved in negative regulation of anoikis	IMP IMP: Inferred from mutant phenotype	15006356	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	10022831	GOA
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19460962	GOA
involved in wound healing, spreading of epidermal cells	IEP IEP: Inferred from expression pattern	14970227	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	17158881	GOA
colocalizes with cell-cell junction	IDA IDA: Inferred from direct assay	14970227	GOA
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	14970227	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	17158881	GOA
part of integrin alpha5-beta1 complex	IDA IDA: Inferred from direct assay	31331973	GOA
part of integrin alpha5-beta1 complex	IPI IPI: Inferred from physical interaction	22451694	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19141530	GOA
colocalizes with ruffle membrane	IDA IDA: Inferred from direct assay	14970227	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA5 Protein Structure

FG-GAP

Integrin_alpha2

0
200
400
600
800
1049 a.a.

Protein Preferred Names

Protein Names

integrin alpha-5

CD49 antigen-like family member E

Recombinant ITGA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72533	ITGA5 Protein, Human (HEK293, His)	P08648 (F42-Y995)	≥95%
HY-P73872	Integrin alpha 5 beta 1 Protein, Human (HEK293, Flag-His)	P08648 (F42-Y995) & P05556-1 (Q21-D728)	≥95%
HY-P77718	Integrin alpha 5 beta 1 Protein, Human (HEK293, His-Avi)	P08648 (F42-Y995)&P05556 (Q21-D728)	≥95%

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Colorectal Cancer, Hereditary Nonpolyposis, Type 8

HNPCC8	Hereditary Nonpolyposis Colorectal Cancer Type 8
Hereditary Non-Polyposis Colorectal Cancer 8	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Kaposi'S Sarcoma-Associated Herpesvirus
Multiple Idiopathic Pigmented Hemangiosarcoma	Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To
African Lymphadenopathic Kaposi'S Sarcoma	Anal Kaposi'S Sarcoma
Cardiac Kaposi'S Sarcoma	Central Nervous System Kaposi'S Sarcoma
Conjunctival Kaposi'S Sarcoma	Corneal Kaposi'S Sarcoma
Cutaneous Kaposi'S Sarcoma	Esophageal Kaposi'S Sarcoma
Gallbladder Kaposi'S Sarcoma	Gastric Kaposi'S Sarcoma
Intestinal Kaposi'S Sarcoma	Kaposi'S Sarcoma Of Anus
Kaposi'S Sarcoma Of Central Nervous System	Kaposi'S Sarcoma Of Conjunctiva
Kaposi'S Sarcoma Of Cornea	Kaposi'S Sarcoma Of Esophagus
Kaposi'S Sarcoma Of Gastrointestinal Sites	Kaposi'S Sarcoma Of Heart
Kaposi'S Sarcoma Of Lymph Nodes	Kaposi'S Sarcoma Of Penis
Kaposi'S Sarcoma Of Skin	Kaposi'S Sarcoma Of Soft Tissues
Kaposi'S Sarcoma Of The Cns	Kaposi'S Sarcoma Of The Gallbladder
Kaposi'S Sarcoma Of The Prostate	Kaposi'S Sarcoma, Lung
Kaposi'S Sarcoma, Skin	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Prolapse Of Urethra

Urethrocele

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Intrahepatic Bile Duct Adenoma

Adenoma Of Intrahepatic Bile Duct

Adenoma Of The Intrahepatic Bile Duct

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06952	ITGA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ITGA5	VGNC	VGNC:42127
Macaca mulatta	ITGA5	VGNC	VGNC:73779
Bos taurus	ITGA5	VGNC	VGNC:30317
Rattus norvegicus	ITGA5	RGD	RGD:2925
Felis catus	ITGA5	VGNC	VGNC:67843
Mus musculus	ITGA5	MGD	MGI:96604
Others	ITGA5	NCBI

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