ARCN1 - archain 1 Gene

Homo sapiens

Also known as COPD; SSMG; SRMMD

Gene ID: 372 | Gene type: protein coding

About ARCN1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,572,409-118,603,033 (from NCBI)

This gene has 4 transcripts (splice variants), 233 orthologues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 45.3), urinary bladder (RPKM 37.0) and 25 other tissues.

Summary

This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic Cell Biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]

ARCN1 Products(2)

mRNA	Protein	Name
NM_001142281.2	NP_001135753.1	coatomer subunit delta isoform 2
NM_001655.5	NP_001646.2	coatomer subunit delta isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARCN1 Protein Structure

Clat_adaptor_s

Adap_comp_sub

0
100
200
300
400
511 a.a.

Protein Preferred Names

Protein Names

coatomer subunit delta

COPI coat complex subunit delta

ARCN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARCN1	P48444	LBHD1	Homo sapiens	Q9BQE6-2	Validated Y2H	32296183
Intra	ARCN1	P48444	LBHD1	Homo sapiens	Q9BQE6-2	Y2H Array	32296183
Intra	ARCN1	P48444	LBHD1	Homo sapiens	Q9BQE6-2	Y2H Prey Pooling	32296183
Intra	ARCN1	P48444	COPB1	Homo sapiens	P53618	Validated Y2H	32296183
Intra	ARCN1	P48444	COPB1	Homo sapiens	P53618	Y2H Array	32296183
Intra	ARCN1	P48444	COPB1	Homo sapiens	P53618	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Short Stature-Micrognathia Syndrome

Short Stature, Rhizomelic, With Microcephaly, Micrognathia, And Developmental Delay	SRMMD
SSMG

Parainfluenza Virus Type 3

Human Parainfluenza Virus Type 3

Piv3

Cataract 28

CTRCT28	Cataract, Age-Related Cortical, 1
Arcc1	Cataract 28, Age-Related Cortical, Susceptibility To
Cataract 28, Age-Related Cortical	Age-Related Cortical Cataract 1

Cataract 6, Multiple Types

Ctpp1	Cataract 6 Multiple Types
CTRCT6	Cataract, Posterior Polar, 1
Arcc2	Cataract, Age-Related Cortical, 2
Ctpa	Ctpp
Age Related Cortical Cataract 2	Posterior Polar Cataract 1
Posterior Polar Cataract, 1	Age-Related Cortical Cataract 2
Cataract Posterior Polar 1

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00891	ARCN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARCN1	VGNC	VGNC:69999
Bos taurus	ARCN1	VGNC	VGNC:26057
Rattus norvegicus	ARCN1	RGD	RGD:1359110
Canis familiaris	ARCN1	VGNC	VGNC:38028
Mus musculus	ARCN1	MGD	MGI:2387591
Felis catus	ARCN1	VGNC	VGNC:68008

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