DND1 - DND microRNA-mediated repression inhibitor 1 Gene

Homo sapiens

Also known as RBMS4

Gene ID: 373863 | Gene type: protein coding

About DND1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,670,794-140,673,576 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 7.3), colon (RPKM 6.1) and 25 other tissues.

Summary

This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

DND1 Products(1)

mRNA	Protein	Name
NM_194249.3	NP_919225.1	dead end protein homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	18155131	GOA
NOT enables miRNA binding	IDA IDA: Inferred from direct assay	18155131	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	28297718	GOA
involved in negative regulation of miRNA-mediated gene silencing	IDA IDA: Inferred from direct assay	18155131	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18155131	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18155131	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DND1 Protein Structure

RRM_1

DND1_DSRM

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

dead end protein homolog 1

RNA-binding motif, single-stranded-interacting protein 4

Related Diseases

Diseases

Alias

Tongue Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Tongue

Pharynx Squamous Cell Carcinoma

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Testicular Disease

Testicular Dysfunction	Testicular Diseases
Disorder Of Testis	Testis Disorder
Testicular Disorders

Spermatocytoma

Spermatocytic Seminoma

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03899	DND1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DND1	VGNC	VGNC:28138
Rattus norvegicus	DND1	RGD	RGD:1583648
Mus musculus	DND1	MGD	MGI:2447763
Macaca mulatta	DND1	VGNC	VGNC:110471
Canis familiaris	DND1	VGNC	VGNC:40028

Name
Email *

	Sorry, but the email address you supplied was invalid.