DRAXIN - dorsal inhibitory axon guidance protein Gene

Homo sapiens

Also known as UNQ3119; neucrin; AGPA3119; C1orf187

Gene ID: 374946 | Gene type: protein coding

About DRAXIN

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,686,635-11,725,857 (from NCBI)

This gene has 1 transcript (splice variant) and 198 orthologues. Low expression observed in reference dataset.

Summary

Predicted to be involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of neuron apoptotic process. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

DRAXIN Products(1)

mRNA	Protein	Name
NM_198545.4	NP_940947.3	draxin precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	29503192	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26190107	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRAXIN Protein Structure

Draxin

0
100
200
300
349 a.a.

Protein Preferred Names

Protein Names

draxin

dorsal repulsive axon guidance protein

Recombinant DRAXIN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76878	Draxin Protein, Human (HEK293, His)	Q8NBI3 (G26-V349)	≥95%

Related Diseases

Diseases

Alias

Third Cranial Nerve Disease

Disorder Of Oculomotor Nerve	Oculomotor Nerve Disorder
Oculomotor Nerve Paralysis	Third Cranial Nerve Disorder

Mirror Movements 1

Congenital Mirror Movement Disorder	Bimanual Synergia
Congenital Mirror Movements	Familial Congenital Controlateral Synkinesia
Familial Congenital Mirror Movements	Hereditary Congenital Controlateral Synkinesia
Hereditary Congenital Mirror Movements	Isolated Congenital Controlateral Synkinesia
Isolated Congenital Mirror Movements	Mirror Movements
MRMV1	Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum
Mirror Movements, Congenital	Bimanual Synkinesis
Cmm	Mirror Movements, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03990	DRAXIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DRAXIN	MGD	MGI:1917683
Macaca mulatta	DRAXIN	VGNC	VGNC:106352
Bos taurus	DRAXIN	VGNC	VGNC:28204
Rattus norvegicus	DRAXIN	RGD	RGD:1585098
Canis familiaris	DRAXIN	VGNC	VGNC:40090
Felis catus	DRAXIN	VGNC	VGNC:61622
Others	DRAXIN	NCBI

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