NTN3 - netrin 3 Gene

Homo sapiens

Also known as NTN2L

Gene ID: 4917 | Gene type: protein coding

About NTN3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,471,297-2,474,145 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues and 27 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Predicted to be located in Golgi apparatus and extracellular region. Predicted to be active in basement membrane. [provided by Alliance of Genome Resources, Apr 2022]

NTN3 Products(1)

mRNA	Protein	Name
NM_006181.3	NP_006172.1	netrin-3 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26190107	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTN3 Protein Structure

Laminin_N

Laminin_EGF

NTR

0
100
200
300
400
500
580 a.a.

Protein Preferred Names

Protein Names

netrin-3

Netrin-2, chicken, homolog of, like

NTN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NTN3	O00634	DRAXIN	Homo sapiens	Q8NBI3	AVEXIS	26190107

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 86

DFNB86	Autosomal Recessive Nonsyndromic Deafness 86
Autosomal Recessive Deafness 86	Deafness, Autosomal Recessive, 86
Deafness, Nonsyndromic, Autosomal Recessive, Type 86

Optic Nerve Hypoplasia, Bilateral

Optic Nerve Hypoplasia	Bilateral Optic Nerve Hypoplasia
Optic Nerve Hypoplasia, Familial Bilateral	Familial Bilateral Optic Nerve Hypoplasia
Isolated Optic Nerve Hypoplasia/Aplasia	Optic Nerve Aplasia, Bilateral
Onh	BONH
Bilateral Optic Nerve Aplasia	Hypoplasia, Optic Nerve, Bilateral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09622	NTN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NTN3	VGNC	VGNC:44008
Mus musculus	NTN3	MGD	MGI:1341188
Rattus norvegicus	NTN3	RGD	RGD:619811
Felis catus	NTN3	VGNC	VGNC:68577
Bos taurus	NTN3	VGNC	VGNC:32305
Macaca mulatta	NTN3	VGNC	VGNC:104741
Others	NTN3	NCBI

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