PEAR1 - platelet endothelial aggregation receptor 1 Gene

Homo sapiens

Also known as JEDI; MEGF12

Gene ID: 375033 | Gene type: protein coding

About PEAR1

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,893,718-156,916,429 (from NCBI)

This gene has 7 transcripts (splice variants), 114 orthologues and 1 paralogue. Broad expression in fat (RPKM 9.8), placenta (RPKM 6.3) and 24 other tissues.

Summary

PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]

PEAR1 Products(3)

mRNA	Protein	Name
NM_001080471.3	NP_001073940.1	platelet endothelial aggregation receptor 1 isoform 1 precursor
NM_001353682.2	NP_001340611.1	platelet endothelial aggregation receptor 1 isoform 2
NM_001353683.2	NP_001340612.1	platelet endothelial aggregation receptor 1 isoform 2

PEAR1 Protein Structure

hEGF

Laminin_EGF

hEGF

Laminin_EGF

hEGF

0
200
400
600
800
1037 a.a.

Protein Preferred Names

Protein Names

platelet endothelial aggregation receptor 1

multiple EGF-like domains protein 12

Related Diseases

Diseases

Alias

Aspirin Allergy

Acetylsalicylic Acid Allergy

Asa Allergy

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10312	PEAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PEAR1	MGD	MGI:1920432
Felis catus	PEAR1	VGNC	VGNC:64108
Rattus norvegicus	PEAR1	RGD	RGD:1305653
Canis familiaris	PEAR1	VGNC	VGNC:44408
Macaca mulatta	PEAR1	VGNC	VGNC:106468
Bos taurus	PEAR1	VGNC	VGNC:32734
Others	PEAR1	NCBI

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